Associations of Mid-Childhood Bisphenol A and Bisphenol S Exposure with Adolescent Obesity

Gajjar, Priya

Full Metadata

Overview

Year:: 2021
Contributor:: Gajjar, Priya (creator); Li, Nan (Reader); Braun, Joseph (Advisor); Brown University. Department of Epidemiology (sponsor)
Genre:: theses
Subject:: Epidemiology
Extent:: v, 38 p.

Files

Description

Abstract:: Background: Epidemiological studies suggest that Bisphenol A (BPA) exposure may increase adiposity in children. Bisphenol S (BPS), a structural analog of BPA, is increasingly used as a BPA substitute. However, few studies have examined the health effects of BPS in children. Objectives: We estimated the association of BPA and BPS exposure at age 8 years with adiposity measures at 8 and 12 years of age and adipocytokine concentrations at 12 years. Methods: We quantified urinary BPA and BPS concentrations in 212 8-year old children from the HOME Study, a prospective pregnancy and birth cohort study that enrolled pregnant women in Cincinnati, Ohio (2003-2006). We assessed children’s adiposity at 8 years using anthropometry (n=212) and bioelectric impedance and at 12 years using dual energy X-ray absorptiometry (n=181). We measured serum adipocytokine concentrations in children at 12 years of age (n=155). Using multivariable linear regression models, we estimated covariate-adjusted associations of log10-transformed BPA and BPS with adiposity measures at 8 and 12 years and log10-transformed adiponectin and leptin concentrations at 12 years. Results: BPA concentrations was inversely associated with body fat percentage at age 8 years (β=-1.2 95%CI: -3.4, 1.0), whereas BPS was positively associated with this measure (β=1.1 95% CI: -0.6, 2.7); the 95% CIs of these estimates included the null. Similarly, BPA was inversely associated with visceral fat area (β=-2.2 95%CI: -10.9, 6.4), whereas BPS was positively associated. (β=0.8 95% CI: -5.5, 7.2). BPA and BPS were not associated with serum adiponectin and leptin concentrations at 12 years of age. There was some evidence that sex modified the association between BPS concentrations and waist circumference at age 8 years (interaction p-value=0.13), with positive associations in girls (β=1.4 95% CI: -1.6, 4.5) and null associations in boys (β-1.2 95% CI: -4.8, 2.3). Conclusions: We did not observe evidence of an association of BPA or BPS concentrations during childhood with measures of child adiposity at age 8 years or 12 years in this cohort.
Notes:: Thesis (Sc. M.)--Brown University, 2021

Content

Citation

Gajjar, Priya, "Associations of Mid-Childhood Bisphenol A and Bisphenol S Exposure with Adolescent Obesity" (2021). Epidemiology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://repository.library.brown.edu/studio/item/bdr:ekvf5wbr/

Relations

Collection:

Epidemiology Theses and Dissertations

Theses and Dissertations for the Epidemiology department.
...