Looking Beyond the Microscope—the Association of DNA Methylation Markers for Periodontal Disease and Lung Cancer Risk

Mulvaney, Rachel

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Overview

Year:: 2022
Contributor:: Mulvaney, Rachel (creator); Michaud, Dominique (Advisor); Kelsey, Karl (Reader); Brown University. Department of Epidemiology (sponsor)
Genre:: theses
Subject:: epigenetics; DNA--Methylation; Lung Cancer; Periodontal disease
Extent:: vi, 10 p.

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Abstract:: Background: Periodontal disease and DNA methylation markers have separately been associated with lung cancer risk. Evaluating methylation levels at two relevant genomic regions that serve as biomarkers for periodontal disease may provide further information pertaining to shared risk factors for periodontal disease and lung cancer development. Methods: In a nested case-control study, we measured DNA methylation levels in samples collected from 416 participants (208 cases; 208 controls) in the CLUE II cohort. We examined ten DNA methylated CpG sites located in two genomic regions, homeobox 4 and zinc finger protein, and their relation to lung cancer risk using conditional logistic regression adjusting for immune cells, batch effects and BMI. Results: Among the ten CpG sites, methylations levels at three sites in HOXA4 were statistically significant for lung cancer risk: CG07317062 (OR=1.59, 95% CI=1.24-2.04), CG11410718 OR=1.42, 95% CI=1.16-1.74), and CG04295144 (OR=1.39, 95% CI=1.04-1.86). Methylation levels of CpG sites in the ZFP57 gene were not associated with lung cancer risk. Conclusion: This study provided some evidence that hypermethylated CpGs in the HOXA4 gene increases the odds of having lung cancer by 59%, 42% and 39% for 1 SD increase in methylation level. Additional research is required to further evaluate how HOXA4 is impacting both periodontal disease and lung cancer risk.
Notes:: Thesis (M. P. H.)--Brown University, 2022

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Citation

Mulvaney, Rachel, "Looking Beyond the Microscope—the Association of DNA Methylation Markers for Periodontal Disease and Lung Cancer Risk" (2022). Epidemiology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://repository.library.brown.edu/studio/item/bdr:kn5aywsm/

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Epidemiology Theses and Dissertations

Theses and Dissertations for the Epidemiology department.
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