- Title Information
- Title
- Induction of mesophase in polycaprolactone and its effect on the long-term delivery of Meloxicam
- Type of Resource (primo)
- dissertations
- Name:
Personal
- Name Part
- Sharan, Raj
- Role
- Role Term:
Text
- creator
- Name:
Personal
- Name Part
- Mathiowtiz, Edith
- Role
- Role Term:
Text
- Advisor
- Name:
Personal
- Name Part
- Morgan, Jeffrey
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Darling, Eric
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology
- Role
- Role Term:
Text
- sponsor
- Origin Information
- Copyright Date
- 2022
- Physical Description
- Extent
- vi, 35 p.
- digitalOrigin
- born digital
- Note:
thesis
- Thesis (Sc. M.)--Brown University, 2022
- Genre (aat)
- theses
- Abstract
- Implants are a viable drug delivery vehicle that can provide a consistent release of drug into the blood. Many implants are made with polymers, such as polycaprolactone (PCL). PCL can be processed to induce mesomorphic content in its structure. Mesophases are relatively unexplored in relation to their effects on long-term drug delivery. This study aimed to induce mesomorphic content in drug loaded PCL formulations and to investigate whether the morphology had an effect of long-term drug release kinetics.
Meloxicam (MLX) loaded PCL samples were processed through the application of pressure and heat. Three processing methods were used in the study to induce mesomorphic content in the samples. The first press method included an application of 10,000 lbs of pressure. The second press methods added the application of heat at 25°C or 50°C. Samples that included PCL loaded with 5%, 10%, and 20% MLX were tested for morphological content and release of drug over 90 days. Mesomorphic content was induced in all three processing methods. The mesomorphic content in the processed samples stayed constant through the entire 90 days in sink conditions. The MLX slowly released over the 90 days, with no sample reaching total drug release. The first press processing method provided the slowest release rate for all drug loadings. 10% MLX loaded samples released the slowest across all processing methods, and 5% MLX loaded samples released the fastest.
Mesomorphic content was successfully induced in drug-loaded PCL formulations. The application of pressure was determined to be the main factor for the induction of mesomorphic content in the samples because there were no significant differences in induced mesomorphic content amongst the three processing methods. Additionally, processed formulations created in this study were able to demonstrate long-term drug release. Since the samples did not even reach 50% of drug released over the 90 day period, the formulations could release drug for an even longer amount of time. 5% MLX loaded samples released quicker than the larger drug loaded samples, meaning that larger drug loadings in similar formulations may be viable for future use in patients.
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01070588")
- Topic
- Polymers
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/01070574")
- Topic
- Polymeric drug delivery systems
- Subject
- Topic
- mesophase
- Subject
- Topic
- long-term drug delivery
- Subject (fast)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/00898666")
- Topic
- Drug delivery devices
- Language
- Language Term (ISO639-2B)
- English
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20220706