Acute T-cell Lymphoblastic Leukemia Presenting with Cardiac Encasement and Pericardial Tamponade Cherala, Rasan Medicine, Warren Alpert Medical School at Brown University author Quynh Lan Dao Medicine, Warren Alpert Medical School at Brown University author A 52-year-old woman with a history of breast cancer treated previously with doxorubicin, cyclophosphamide, and radiation therapy presented with subacute onset of dyspnea and tachycardia. She was found to have T cell acute lymphoblastic leukemia (T-ALL) with a mediastinal mass encasing the heart and a large pericardial effusion with tamponade. We highlight how this rare hematologic malignancy may initially present as pericardial tamponade, and specifically discuss presenting symptoms of subacute pericardial tamponade. Further, we discuss presentation, prognosis and management of T-ALL. articles Case Reports Summer 2022 2022-07 eng pp. 1-4 born digital We present a case of acute psychosis in a patient with panhypopituitarism admitted for adrenal crisis secondary to insufficient glucocorticoid replacement 02 no. 1 4 Brown Journal of Hospital Medicine Issue 02 Cardiac tamponade Lymphomas Leukemia pericardial tamponade cardiac encasement T-cell acute lymphoblastic lymphoma T-ALL T-cell acute lymphoblastic leukemia T-LBL Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) In Copyright 10.26300/z494-4f09