<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-7.xsd"><mods:titleInfo><mods:title>Assessing Risk Factors Associated with Incidental Findings  in Low-Dose CT Lung Cancer Screenings</mods:title></mods:titleInfo><mods:typeOfResource authority="primo">dissertations</mods:typeOfResource><mods:name type="personal"><mods:namePart>Xi, Kevin</mods:namePart><mods:role><mods:roleTerm type="text">creator</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Gareen, Ilana</mods:namePart><mods:role><mods:roleTerm type="text">Advisor</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Joyce, Nina</mods:namePart><mods:role><mods:roleTerm type="text">Reader</mods:roleTerm></mods:role></mods:name><mods:name type="corporate"><mods:namePart>Brown University. Department of Epidemiology</mods:namePart><mods:role><mods:roleTerm type="text">sponsor</mods:roleTerm></mods:role></mods:name><mods:originInfo><mods:copyrightDate>2025</mods:copyrightDate></mods:originInfo><mods:physicalDescription><mods:extent>2, 25 p.</mods:extent><mods:digitalOrigin>born digital</mods:digitalOrigin></mods:physicalDescription><mods:note type="thesis">Thesis (M. P. H.)--Brown University, 2025</mods:note><mods:genre authority="aat">theses</mods:genre><mods:abstract>Background &amp; Aims &#13;
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Significant Incidental Findings (SIFs) are widely reported in patients undergoing Low-dose CT (LDCT) lung screenings. Using data from the National Lung Screening Trial (NLST), we aim to identify occupational and medical conditions that may be associated with the detection of a SIF either with or without lung cancer at screening. &#13;
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Methods &#13;
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We analyzed data from the National Lung Screening Trial (NLST) which screened 53,452 participants accrued at 33 U.S. health centers.  Participants were aged 55-74 at study entry, all current or former smokers who quit within the past 15 years. Participants were categorized based on whether they ever had a Significant Incidental Finding (SIF) and/or findings suspicious for Lung Cancer (POS) detected at screening during the National Lung Screening Trial, leading to 4 distinct outcome categories of ever POS only, ever SIF only, ever both POS/SIF, and always NEG.  &#13;
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We used multinomial logistic regression to determine the covariate-adjusted association of occupational, medical condition, and smoking-related risk factors on NLST screening results for POS, POS/SIF, SIF, and NEG. Exposures of interest included pack years, years since quitting, cohabitation with smokers, coworking with smokers, comorbidity history, history of high-risk employment, and disease history. Confounding variables adjusted for included age, gender, race/ethnicity, education, and BMI.  &#13;
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Results &#13;
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No evidence was found of an increased association between occupational exposures and POS/SIF or SIF screening outcome. The exception was occupational history of cotton jute processing (OR 0.497, p=0.03) which was found to be inversely associated with POS/SIF screening outcome. The odds of POS/SIF screening outcome increased by 0.3% (OR 1.003, p=0.006) for each additional pack year smoked, and increased by 2.2% (OR 1.02, p&lt;0.001) for each year older a participant was when they stopped smoking.  &#13;
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Conclusion &#13;
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Amongst the NLST screening population, occupational exposures did not appear to increase the likelihood of SIF detection during lung screening.</mods:abstract><mods:subject authority="fast" authorityURI="http://id.worldcat.org/fast" valueURI="http://id.worldcat.org/fast/00914091"><mods:topic>Epidemiology</mods:topic></mods:subject><mods:subject><mods:topic>significant incidental findings</mods:topic></mods:subject><mods:subject><mods:topic>multinomial model</mods:topic></mods:subject><mods:language><mods:languageTerm authority="iso639-2b">English</mods:languageTerm></mods:language><mods:recordInfo><mods:recordContentSource authority="marcorg">RPB</mods:recordContentSource><mods:recordCreationDate encoding="iso8601">20250707</mods:recordCreationDate></mods:recordInfo></mods:mods>