Antibiotic resistance is an urgent threat to public health. For this reason, new antimicrobial therapies are constantly needed to treat ever-evolving pathogens. One such pathogen …
Pseudogymnoascus destructans is the invasive fungal pathogen responsible for White-Nose Syndrome (WNS), a devastating disease affecting North American bats. WNS has led to the loss …
Eukaryotic organisms undergo changes in morphology in order to survive and proliferate within a variety of different environments and conditions. The human fungal pathogen Candida …
Cryptococcosis infection from Cryptococcus neoformans (C. neoformans) remains a global health threat. It is an encapsulated yeast saprophyte that mainly afflicts individuals with compromised immune …
Candida albicans is an opportunistic human fungal pathogen that can adapt to fluctuating host environments by both genetic and epigenetic mechanisms. In this study, the …
Abstract of Disruption of yfjD Gene in Francisella, by Japheth Omonira, ScM., Brown University, May 2018. Francisella tularensis is the causative agent of tularemia, a …
Host-microbe interactions heavily influence both fitness and disease. Traditionally, research on host-microbe interactions focused on the concept that microbes only contribute to pathogenesis. However, recent …
The rise of antibiotic-resistant bacteria poses a threat to human health across the globe. In order to protect ourselves, it is imperative to identify novel …
Understanding how cellular activities impact genome stability is critical to multiple biological processes including tumorigenesis and reproductive biology. The fungal pathogen Candida albicans displays striking …
The opportunistic fungal pathogen Candida albicans is capable of colonizing diverse host niches throughout the human body. The ability of C. albicans to undergo a …
The gut microbiome is incredibly stable, however, it is unknown how this stability is maintained. How organisms are spatially organized within their ecosystem influences community …
The oral cavity is home to the second-largest microbiome in the human body. Its size is partly due to the large surface area, and multi-compartmentalization …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic. In addition to the acute pulmonary symptoms of COVID-19 (the disease associated …
Throughout the course of evolution, one of the key driving forces that elaborately defined the relationship between the gut microbiome and the mammalian host was …
Abstract of β-Lactamase Responsive Delivery of Bacteriophages for the Treatment of Multidrug Resistant Pseudomonas aeruginosa, by Alison M Veintimilla, ScM, Brown University, May, 2022. Antibiotic …
