Structural features of proteins often serve as signatures of their biological function and molecular binding activity. Elucidating these structural and dynamical features is essential for …
In genetics, one fundamental goal is to understand which mutations in the human genome have significant effects on complex traits and diseases. Achieving this goal …
As data structures become larger and more complex, methods of data analysis must evolve to harness the most accurate insights. Inspired by the challenges presented …
Development is a complex process governed by coordinated gene regulation at a precise time and place. Uncovering how transcription factors (TFs) and their targets communicate …
This dissertation is motivated by complex data architectures—typical in genetics research—that break the assumptions of classical frequentist analyses. Predictors are not necessarily independent nor fewer …
The rise of antimicrobial resistant (AMR) bacteria is one of the world's most pressing public health crises, and our fight against such AMR bacteria is …
Metagenomic sequencing is a novel method for viral detection in biomanufacturing that has the potential to displace current detection methods because of its capacity for …