A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This modification …
Ten years ago, the first RNA-seq study was published. Since then over 200 thousand RNA-seq studies have been published, spanning many different organisms, tissue types, …
Antimicrobial resistance poses a global challenge to human health that is only expected to increase without significant treatment innovations. Novel therapeutic strategies are needed for …
First detected in Rwanda, recent monitoring has detected multiple emerging Plasmodium falciparum kelch13 (K13) propeller gene mutations across East Africa. Mutations, such as R561H in …
Alternative splicing in the nervous system is an important regulator of neuronal function. CaV2.2 calcium channels control neurotransmission and are extensively alternatively spliced in a …
Cancer is caused largely by the accumulation of somatic mutations throughout an individual's life. Recent advances in next generation sequencing (NGS) enable measurement of somatic …
Polycomb Group (PcG) epigenetic regulators are important but not well-understood components of cellular senescence. EZH2, a PcG histone H3 lysine-27 methyltransferase, is repressed in senescent …
Cellular senescence and aging are associated with extensive chromatin and transcriptional changes. We examined cell-free DNA (cfDNA) in individuals of different age groups to elucidate …
Fungal pathogens utilize a variety of strategies to adapt to environmental cues and to thrive in different host niches. This includes phenotypic switching, in which …
Abstract of “The chromatin and transcriptional landscape of senescent cells”, by Steven W. Criscione, Ph.D., Brown University, May 2017 Senescent cells are recognized as one …
Ser/Thr phosphatases dephosphorylate their targets with high specificity, yet the structural determinants of substrate recognition and dephosphorylation are poorly understood. Calcineurin (CN) is a conserved …
Biofilms are communities of bacterial cells that are encapsulated in a self-produced polymeric matrix that can attach to almost any surface [10]. Formation of these …
