Bone Morphogenetic Proteins (BMPs) are present almost everywhere in the body. They have various functions, which makes the question of how the BMP signal is …
Cell division is fundamental to life. As more divergent organisms become tractable to genetic manipulation, we have discovered that the molecular mechanisms that govern cell …
T cell receptor (TCR) activation, driven by the phosphorylation of tyrosine kinases, is crucial in mounting proper adaptive immune responses. Although major kinases and phosphatases …
Gamete fusion is an essential step in sexual reproduction, requiring the merger of plasma membranes and genetic material from two gametes to produce a single …
Abstract of “GA-Binding Proteins Regulate Dosage Compensation in Drosophila melanogaster” by Emily Grace Kaye, Ph.D., Brown University, May 2018 A transcription factor (TF) will bind …
Cellular heterogeneity is a confounding issue for many cellular populations, and this is especially true for the study and use of adipose-derived stem/progenitor cells, or …
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) and FUsed in Sarcoma (FUS) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that affects glutamatergic and …
Nearly half of the human genome is comprised of mobile genetic elements known as transposons. Most transposons in humans can no longer create new copies …
Biomolecular condensates are a relatively recent addition to our understanding of cellular compartmentalization, existing within cells as phase-separated compartments of RNA and protein that remain …
Antimicrobial resistance is a major problem and according to Centers for Disease Control and Prevention (CDC) it causes about 2.8 million antimicrobial-resistant infections every year …
Ovarian cancer is the second most common gynecological cancer, and it is one of the most lethal types of malignancy. The 5-year relative survival rate …
Macrophage migration inhibitory factor (MIF) and its homolog MIF-2 are cytokine-like proteins with critical roles in immunomodulation that are upregulated in various inflammatory diseases. These …
Abstract of Molecular Studies of Allosteric Motion and Crosstalk in the Thermophilic CRISPR-Cas9, by Helen Barivieira Belato, Ph.D, Brown University, February 2024. One of the …
Cell signaling pathways are essential for multicellular organisms, for the coordination of development and physiology. Diversification of the conserved Transforming Growth Factor-β (TGF-β) and Bone …
The protein ser/thr phosphatases (PSPs) dephosphorylate over 2000 of key biological targets, making them attractive therapeutic targets. The serine/threonine protein phosphatases 1 and 2B (PP1; …
Biofilms are communities of bacterial cells that are encapsulated in a self-produced polymeric matrix that can attach to almost any surface [10]. Formation of these …