BioLuminescent-OptoGenetic molecules for driving and imaging neural activity have a number of advantages in vivo. In this approach, genetically expressed luciferases bind with injected luciferins …
Over recent years miniature microscopes have become a key tool for in vivo free behavioral studies. This technology offers the ability to measure network dynamics …
This is a movie showing bioluminescence of the Choroid Plexus in a transgenic mouse expressing the LMO3 molecule. Water-Soluble Coelenterazine (CTZ) by Nanolight was injected …
This is a movie showing bioluminescence in left primary somatosensory cortex in a mouse expressing the LMO3 molecule. Water-Soluble Coelenterazine (CTZ) by Nanolight was injected …
This is a movie showing bioluminescence in left primary somatosensory cortex in a mouse expressing the LMO3 molecule. Water-Soluble Coelenterazine (CTZ) by Nanolight was injected …
This is a movie showing Calcium Dependent Bioluminescence in a mouse expressing LMC4 in left primary somatosensory cortex. Water soluble Coelenterazine (CTZ) was injected in …
This is a movie showing Calcium Dependent Bioluminescence in a mouse expressing LMC4 in left primary somatosensory cortex. Water soluble Coelenterazine (CTZ) was injected in …
Bioluminescent molecules for imaging and modifying neural activity are increasingly becoming viable tools for in vivo use and have the potential to overcome many of …
As an alternative to fluorescent imaging, we are developing calcium-dependent, genetically-encoded molecules using bioluminescent probes. Bioluminescence is chemically generated light that occurs when a photon-containing …
