In this thesis we provide evidence that the FAIRE method can reveal interesting and relevant changes in genome-wide chromatin organization as cells undergo replicative senescence, …
Despite many studies linking FOXO factors to longevity, how these factors directly regulate aging particularly in humans, is not completely understood. The focus of this …
Abstract of ‘Ecdysone-Regulated DNA Amplification in Sciara coprophila’, by Léo Kadota, Sc.M., Brown University, May 2017. The eukaryotic genome contains thousands of origins (ORIs) of …
Polycomb Group (PcG) epigenetic regulators are important but not well-understood components of cellular senescence. EZH2, a PcG histone H3 lysine-27 methyltransferase, is repressed in senescent …
Cellular senescence and aging are associated with extensive chromatin and transcriptional changes. We examined cell-free DNA (cfDNA) in individuals of different age groups to elucidate …
In eukaryotes, DNA is first transcribed into precursor-messenger RNA (pre-mRNA) which is then followed by extensive RNA processing events. One such event is RNA splicing, …
Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes that produce the majority of cellular energy …
Mutations in the SLC13A5 gene, which encodes a plasma membrane citrate transporter, result in developmental epileptic encephalopathy (DEE25), a disorder characterized by infantile multi-focal seizures, …
Aging is generally defined as the progressive and time-dependent loss of function accompanied by increasing vulnerability to diseases and mortality. In particular, aging is associated …
The transcription factor MYC is overexpressed in many human cancers and has a significant causal role in tumor incidence and progression. Remarkably, mice with decreased …
Abstract of “The chromatin and transcriptional landscape of senescent cells”, by Steven W. Criscione, Ph.D., Brown University, May 2017 Senescent cells are recognized as one …