Nervous system wiring is accomplished by individual axons sensing a multitude of attractive and repulsive chemical cues in their environment and growing in response to …
T cells are integral to the adaptive immune system and human physiology. A comprehensive understanding T cell signaling pathways can facilitate the utility of T …
RNA-binding proteins (RBPs) interact with a network of other proteins to form ribonucleoprotein (RNP) complexes, which are critical players throughout the lifecycle of RNA. Dysfunction …
Streptomycetes are a large group of Gram-positive, soil-dwelling bacteria that have evolved remarkable metabolic capabilities for survival in a nutrient-poor and a biodiverse ecological niche. …
Macrophage migration inhibitory factor (MIF) and its homolog MIF-2 are cytokine-like proteins with critical roles in immunomodulation that are upregulated in various inflammatory diseases. These …
Subcellular organization is important for maintaining cellular homeostasis within eukaryotic cells. In addition to membrane-bound organelles, membraneless compartmentalization of the cell occurs via liquid-liquid phase …
Subcellular organization is important for maintaining cellular homeostasis within eukaryotic cells. In addition to membrane-bound organelles, membraneless compartmentalization of the cell occurs via liquid-liquid phase …
Abstract of Molecular Studies of Allosteric Motion and Crosstalk in the Thermophilic CRISPR-Cas9, by Helen Barivieira Belato, Ph.D, Brown University, February 2024. One of the …
Cellular homeostasis depends on proper spatiotemporal partitioning of biochemistry. In addition to the classical paradigm of subcellular division through membrane-bound organelles, cells utilize the phenomenon …
Bacterial biofilms underlie the recalcitrance of many harmful infections to antibiotic treatment. One strategy that allows biofilms to evade antibiotics is the presence of a …
Ser/Thr phosphatases dephosphorylate their targets with high specificity, yet the structural determinants of substrate recognition and dephosphorylation are poorly understood. Calcineurin (CN) is a conserved …
Innate regulatory mechanisms ensure that an origin of replication activates at most once per cell cycle. An override of this control results in multiple firings …