The sigma-2 receptor is a pharmacologically-defined protein receptor present in a variety of tissues, and interest in its role in a wide array of diseases …
Abstract: Aging impairs VEGF-A mRNA stability and consequent inflammatory arteriogenesis, by Olivya Caballero, Sc.M, Brown University, May, 2024. Objective: Aging is associated with impaired inflammatory …
This study explored the impact of extracellular matrix (ECM) stiffness on lipid metabolism in polyploid giant cancer cells (PGCCs) and their role in breast cancer …
A major contributing factor to the poor prognosis of patients diagnosed with epithelial ovarian cancer (EOC) is the staggering rates of refractory and resistant disease. …
Ischemia –reperfusion (IR) injury is an unavoidable consequence of the interruption and reintroduction of blood to an organ. During liver transplantation, aged and steatotic donors …
Christianson syndrome (CS) is an X-linked, monogenic, neurological disorder caused by mutations in SLC9A6, the gene encoding Na+/H+ exchanger 6 (NHE6). Symptoms of CS include …
In the spinal cord dorsal horn, persistent changes in synaptic strength may contribute to nociceptive information processing and to pathological pain states. These changes overlap …
Diffuse midline glioma (DMG) is the most aggressive primary brain tumor in children, with <10% surviving more than 2 years post-diagnosis. This tumor is inoperable …
Abstract of Proximity Proteomics to Map Oncogenic Interactomes, by Max Petersen, Ph.D., Brown University, May 2023. All disease is associated with dysregulated protein signal transduction. …
Abstract of “Role of MiRNA-1, MiRNA-145 and MiRNA-365 in Cardiac Remodeling”, by Nedyalka Valkov, Ph.D., Brown University, May 2017. Cardiac remodeling occurs in many cardiovascular …
Tumor recurrence after therapy is a major contributor to breast cancer-related deaths. To avoid recurrent disease, it is important to study mechanisms of chemoresistance. One …
Abstract of Sigma-2 Receptor-Mediated Changes in Metabolism and Calcium Signaling, Degree ScM, Brown University, May 2019 Sigma receptors are a pharmacologically distinct family of membrane-bound …
Sepsis is an immune disorder, defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection”, that remains a significant public health burden. …
The mammalian brain relies on neural stem cells (NSCs) to regenerate and replenish its many different cells throughout the organism’s lifetime, in a process known …
Mitogen-activated protein kinases direct the cellular response to environmental and developmental signals. MAPKs are activated through kinase modules resulting in phosphorylation of the MAPK on …
Expansion of trinucleotide repeat (TNR) DNA is implicated in several neurodegenerative disorders, including Huntington's Disease (HD). Expansion propensity and disease progression is dictated by repeat …
Cardiac myocytes (CM) and fibroblasts (CF) are the two major cell types in the heart. Overall, cardiac remodeling occurs in response to stress on the …
Ischemic heart disease is the leading cause of death globally, which takes more than 17.7 million lives every year (WHO, 2018), yet current treatments and …