Neutrophil-mediated host defense against pathogens includes the extrusion of a lattice of DNA and microbicidal enzymes known as Neutrophil Extracellular Traps (NETs). The receptor:ligand interactions …
Infectious agents pose a significant threat to global health with profound health and economic implications. Particularly concerning is the emergence of epidemic-competent and life-threatening drug-resistant …
Recent developments in mass spectrometer technology has increased the sensitivity and speed to an unprecedented level, along with the continuing improvements of high performance liquid …
Aspartyl-asparaginyl-β-hydroxylase (AAH) is a ~86 kD protein abundantly expressed in hepatocellular carcinoma (HCC) and downregulated by chronic ethanol exposure, contributing to alcoholic liver disease (ALD). …
DNA damage is the primary molecular mechanism responsible for cancer and aging. DNA lesions can derive from oxidation, deamination, or alkylation of the nucleobases. If …
Repair of damaged DNA plays a crucial role in maintaining genomic integrity and normal cell function. The base excision repair (BER) pathway is primarily responsible …
Insulin and IGF signaling (IIS) is a complex system that controls diverse processes including development, metabolism, stress responses and aging. Drosophila melanogaster IIS is propagated …
Efforts to characterize proteins found in the outer membrane of gram-negative bacteria have been steadily increasing due to the promise of expanding our understanding of …
Prions are proteins that can adopt multiple distinct and stable conformations, a properly folded form and a collection of misfolded or prion forms that are …
The conformation of a protein is directly linked to its function. While protein misfolding can perturb that activity, it can also lead to toxic aggregation, …
Our understanding of signaling networks in the physiological context of an organism remains limited, partly due to the technical challenge of identifying serine/threonine phosphorylated peptides …
Abstract of Proximity Proteomics to Map Oncogenic Interactomes, by Max Petersen, Ph.D., Brown University, May 2023. All disease is associated with dysregulated protein signal transduction. …
Reliable quantitation of protein abundance is fundamental in accurately determining differential protein expression associated with biological phenomena such as cell growth and differentiation, disease progression, …
Many naturally occurring peptides and depsipeptides have attracted the interest of medicinal chemists in recent decades due to their broad spectra of bioactivities, such as …
Protein homeostasis is the dynamic process of balancing the constitution of the entire proteome of a living organism. One of the most critical components in …