Meniscus tears are among the most frequent orthopaedic injuries that commonly affect active and young populations. These tears ultimately increase the risk of developing post-traumatic …
Malignant mesothelioma is an aggressive cancer of the mesothelial lining causally linked to asbestos exposure and is highly resistant to current therapies. We hypothesize a …
Cellular heterogeneity is a confounding issue for many cellular populations, and this is especially true for the study and use of adipose-derived stem/progenitor cells, or …
Serous epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy and is associated with accumulation of ascites fluid, which is rich in cell-secreted exosomes. …
Labeling live cells for gene and protein expression is critical to a myriad of research and clinical functions. These include diagnostic imaging, enrichment of heterogeneous …
There is a need for developing novel drug delivery systems (DDSs) to deliver therapeutics to desired sites with low toxicity. In this thesis we designed …
The work in this thesis demonstrates that mesenchymal stem cell (MSC) function is influenced by aging and chemotherapy. Furthermore, these results illustrate that inherent differences …
The stromal vascular fraction (SVF) is a heterogeneous population of cells that resides in adipose tissue. It includes adipose-derived stem cells (ASCs), which work synergistically …
Abstract of “The Role of Mechanical Properties in Stem Cell Adipogenesis” by Nicholas R. Labriola, Ph.D., Brown University, May 2017 The mechanical properties of cells …
Stem cells have shown great promise for the treatment of human disease. However, stem cell therapies are limited by heterogeneous differentiation. As a result, researchers …