This dissertation presents two experimental studies of DNA polymers inside nanofluidic devices with well-defined topographic features. Those features include square pits and rectangular trenches etched …
This work consists of two main projects: the first project describes bacterial confinement within a thin but resilient layer of liquid. The second project reports …
Gradients of voltage, pressure, temperature, and salinity can transport objects in micro- and nanofluidic systems by well known mechanisms. Relatively little experimental work has previously …
This dissertation presents a new technique to increase the accessible noise range in micro and nanofluidics using electrokinetics. We show that the application of voltage …
The research is motivated by some previously-reported conflicting observations and explanations regarding the motility of flagellated bacteria swimming in polymer solutions. Three-dimensional real-time tracking microscopy …
Ovarian cancer is the most lethal gynecological cancer largely due to its late detection after metastasis has occurred. Stromal cells (SCs) promote cancer cell growth …
This dissertation is composed around the subject of multiscale modeling of soft matter and biophysical systems with applications using large-scale computations. Specifically, it is expanded …
My research is motivated by an idea for a new method of sequencing individual biopolymers, including proteins and nucleic acids, that combines mass spectrometry with …
The photoacoustic effect, also frequently called the optoacoustic effect, was discovered by Alexander G. Bell in 1880. The effect refers to the generation of acoustic …
The discipline of protein evolution aims to understand the principles and driving forces whereby new protein-coding genes, protein structures, and biological functions emerge due to …
Active matter systems remain in a far-from-equilibrium state due to the motion generated at small scales by their self-driven constituents. These systems can exhibit complex …
This thesis aims to elaborate the theory of ultrasonic vibration potential imaging as well as to propose and implement new electro-acoustic imaging methodology for biomedical …
Polyploid giant cancer cells (PGCCs) are a commonly observed histological feature of human tumors and are particularly prominent in late stage and drug resistant cancers. …
