Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes that produce the majority of cellular energy …
Coordinate gene regulation is critical to promote normal development and prevent disease. How domains of co-regulation are established in vivo remains poorly understood. X-chromosome dosage …
The bone morphogenetic protein (BMP) signaling pathway is an essential regulator of developmental and cellular processes. Secreted ligands initiate BMP signaling by binding to a …
Dosage compensation in Drosophila is a valuable model for studying how transcription complexes are targeted throughout the genome because all of the genes along the …
In sexual reproduction, fusion of haploid sperm and egg cells (gametes) are required to produce a unique diploid individual that represents the next generation. Despite …
Trinucleotide repeats (TNRs) occur throughout the genome and their expansion can affect varied cellular processes such as gene expression, mRNA processing, and protein folding. TNR …
The conformation of a protein is directly linked to its function. While protein misfolding can perturb that activity, it can also lead to toxic aggregation, …
Fragile X syndrome, a leading cause of autism and the most common form of inherited intellectual disability, results from the loss of Fragile X mental …
Phosphorylation is an essential cellular regulatory mechanism that is conserved from invertebrates to mammals. Despite the simplicity of adding or subtracting a single phosphate molecule, …
Communication between the extracellular matrix and the intracellular environments of the cells is crucial for multiple processes such as survival, proliferation or maintenance of cellular …
mRNA localization is a powerful post-transcriptional mechanism of gene expression that allows for protein expression in distinct cellular locations. This process is exploited in a …
The endoderm germ layer gives rise to the epithelial lining of the respiratory and digestive tracts and their associated organs. Gastrulation and formation of the …
Studying the biological mechanisms of the aging process in the fruit fly Drosophila melanogaster has been crucial to the advancement of the field. In particular, …
The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA. Here, …
Genetically determined, fixed action pattern behaviors offer a useful model for studying how developmental gene expression programs lay down a neuroanatomical architecture that underlies these …
Cells have a robust protein quality control (PQC) network that ensures proteins reach and maintain their proper fold, and breakdowns in this network result in …
Fungal pathogens utilize a variety of strategies to adapt to environmental cues and to thrive in different host niches. This includes phenotypic switching, in which …
Abstract of The role of plastin in motor neuron disease and identifying genetic modifiers of spinal muscular atrophy, by Melissa B. Walsh, Ph. D., Brown …