The conformation of a protein is directly linked to its function. While protein misfolding can perturb that activity, it can also lead to toxic aggregation, …
Cells have a robust protein quality control (PQC) network that ensures proteins reach and maintain their proper fold, and breakdowns in this network result in …
Prions are unique proteins that can exist in multiple states. In the prion form these proteins self-replicate, directing other like molecules to adopt the prion …
The prion hypothesis provides an explanation for a diverse collection of previously inexplicable phenomena, ranging from the appearance, progression and spread of neurodegenerative disease in …