This thesis explores clinical and social factors to characterize underweight malnutrition on the national and global level using the UNICEF Childhood Malnutrition Datasets (survey-level data …
Automation has been rapidly changing the research performed in the scientific community. With more high-throughput technologies available to both academic and industrial scientists, improvements to …
ONC201 is a novel, orally bioavailable small molecule that is the founding member of the imipridone class and is currently in clinical trials for various …
NAFLD affects more than one-quarter of adults worldwide with 60% in diabetic patients and 90% in obese people. Aspartate beta-hydroxylase (ASPH), an alpha-ketoglutarate dependent enzyme …
Manganese (Mn) is an essential dietary nutrient. However, Mn excess can cause irreversible neurological damages often referred to as manganism. While Mn excess is typically …
Sigma receptors are a pharmacologically defined class of intracellular orphan receptors that bind a variety of psychotropic agents. The endogenous function of the sigma-2 receptor …
Background- Angelman syndrome (AS) is a severe cognitive disorder caused by loss of neuronal expression of the E3 ubiquitin ligase UBE3A. Brain-derived neurotrophic factor (BDNF) …
Nervous system wiring is accomplished by individual axons sensing a multitude of attractive and repulsive chemical cues in their environment and growing in response to …
Vision loss and blindness continue to be leading causes of disability both nationally and globally. There has been progress in treating certain causes of blindness, …
Abstract of Human Cell-Based In Vitro Toxicity Testing Landscape: Market Analysis and Trends Report, by Megan Marie Grant, Master of Science, Brown University, May 2020. …
Due to medical advances, premature infants born as early as 22 weeks of gestation can survive. Yet, their lungs are underdeveloped and unable to diffuse …
The revolutionization of capillary electrophoresis (CE) technology has increased research into CE-related issues on long read and ultra-long read lengths for next-generation sequencing (NGS). An …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with symptom-onset occurring in adulthood. ALS is characterized by progressive degeneration of upper and lower motor …
Ubiquitin- proteasome (UPS) and the autophagy- lysosome are the two main systems responsible for degradation and maintaining protein homeostasis in eukaryotic cells. Impairments of either …
Objective: The purpose of this study was to assess the effectiveness of regulations and interventions on head impacts in youth, high-school, and collegiate football, using …
Chitinase 3-Like 1 (CHI3L1) a secreted glycoprotein, has been found to play a role in inflammation, as well as cell survival, growth, and proliferation (Ku …
Polyploid giant cancer cells (PGCCs) are a commonly observed histological feature of human tumors and are particularly prominent in late stage and drug resistant cancers. …
