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Items (1-20) out of 189 results

3D Culture of HepG2 Liver Cancer Cells in Transglutaminase-Crosslinked Gelatin Scaffolds

Description:
Objective: The objective of this thesis was to establish an experimental 3D culture system based on liver cancer (HepG2) cells in a gelatin scaffold and …
Year:
2021
Contributor:
Avila, Mary Flordelys Dizon (creator)
Ip, Blanche (Reader)
Schell, Jacquelyn (Reader)
Wong, Ian (Advisor)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
3D Cell Culture
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

A Data-Driven Approach for Characterizing Childhood and Adult Malnutrition at the National and Global Level

Description:
This thesis explores clinical and social factors to characterize underweight malnutrition on the national and global level using the UNICEF Childhood Malnutrition Datasets (survey-level data …
Year:
2020
Contributor:
DeBare, Mariana L (creator)
Schell, Jacquelyn (Reader)
Chen, Elizabeth (Advisor)
Gillani, Fizza (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Malnutrition in children
Malnutrition--Prevention
Malnutrition--Social aspects
Malnutrition
Malnutrition in the elderly
Malnutrition in the United States
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

A Matter of Life and Death: Novel Ligands Mediating Cytotoxic Function and Revealing Metabolically Stimulative Function of the Sigma-2 Receptor in Human Cancer

Description:
The sigma-2 receptor is a pharmacologically-defined protein receptor present in a variety of tissues, and interest in its role in a wide array of diseases …
Year:
2016
Contributor:
Nicholson, Hilary E (creator)
Bowen, Wayne (Director)
Marshall, John (Reader)
Matsumoto, Rae (Reader)
Oancea, Elena (Reader)
Zhitkovich, Anatoly (Reader)
Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:
theses
Subject:
sigma-2 receptor
CM572
CM764
sigma receptor
cellular metabolism
triple negative breast cancer
Glycolysis
Neuroblastoma
Language:
English
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

A multi-host approach to evaluate antibiotic compounds against methicillin-resistant Staphylococcus aureus

Description:
Antibiotic resistance is an urgent threat to public health. For this reason, new antimicrobial therapies are constantly needed to treat ever-evolving pathogens. One such pathogen …
Year:
2021
Contributor:
White, Alexis (creator)
Mylonakis, Eleftherios (Advisor)
Belenky, Peter (Reader)
Scott, Jeffrey (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Greater wax moth
Caenorhabditis elegans
MRSA
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

A Novel Role for Programmed Cell Death Receptor Ligand 2 (PD-L2) in Sepsis-Induced Hepatic Dysfunction

Description:
Sepsis is defined as a state of life-threatening organ dysfunction due to dysregulated host response to infection. Because of its complex pathogenesis, sepsis is difficult …
Year:
2017
Contributor:
Le, Marilyn C (creator)
Zimmerman, Anita (Reader)
Bowen, Wayne (Reader)
Ayala, Alfred (Advisor)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Immunology
Septicemia
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

A novel target for insulin resistance in ​Nonalcoholic Steatohepatitis

Description:
NAFLD and NASH have caught the attention of scientists to make an accurate diagnosis and find effective treatments. Studies have found that both hyperinsulinemia and …
Year:
2019
Contributor:
Lin, Mengqi (creator)
Wands, Jack (Advisor)
Li, Jisu (Reader)
Zhang, Songhua (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Liver--Diseases
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

A Novel, Context Dependent Two Alternative Forced Choice Task for the Exploration of the Neural Correlates of Higher Order Cognition in Mice

Description:
The brain’s ability to attribute valence to sensory stimuli in our environment and modulate these associations to reflect its current state is essential for goal …
Year:
2017
Contributor:
Gill, Jay Lathen (creator)
Moore, Christopher (Advisor)
Frank, Michael (Reader)
Bath, Kevin (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
behavioral neuroscience
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Accelerating Chemical Synthesis via High-throughput Technologies and Automated Platforms and its Application to Drug Discovery and Molecular Informatics

Description:
Automation has been rapidly changing the research performed in the scientific community. With more high-throughput technologies available to both academic and industrial scientists, improvements to …
Year:
2020
Contributor:
Dombroski, Amanda (creator)
Sello, Jason (Advisor)
Bowen, Wayne (Reader)
Creton, Robbert (Reader)
Basu, Amit (Reader)
Peterson, Randall (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Zebrafish Behavior
GABA-A receptor
Molecular Memory
Automation
Anesthetics
Chemical Library Synthesis
Chemical Computation
Neuropharmacology
High-Throughput Behavioral Analysis
Molecular Informatics
Polypharmacology
Sedatives
Stimulants
Sedation Reversal Agents
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Activating a Cancer-Specific Apoptotic Switch: Preclinical Evaluation of a Novel Combination of ONC201/ONC212 and TRAIL

Description:
ONC201 is a novel, orally bioavailable small molecule that is the founding member of the imipridone class and is currently in clinical trials for various …
Year:
2020
Contributor:
Jhaveri, Aakash Viren (creator)
El-Deiry, Wafik (Advisor)
Bartnikas, Thomas (Reader)
Sanders, Jennifer (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
cancer therapeutics
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Activation of Ano1 is Associated with Apoptosis of Pulmonary Endothelial Cells: Implications for Pulmonary Arterial Hypertension

Description:
Aberrant endothelial cell (EC) proliferation plays an important role in the vascular remodeling observed in Pulmonary Arterial Hypertension (PAH). Anoctamin-1 (Ano1), a calcium activated chloride …
Year:
2016
Contributor:
Allawzi, Ayed M (creator)
Choudhary, Gaurav (Director)
Zimmerman, Anita (Reader)
Rounds, Sharon (Reader)
Harrington, Elizabeth (Reader)
Sham, James (Reader)
Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:
theses
Subject:
Endothelial
pulmonary arterial hypertension
PH
PAH
Anoctamin-1
Ano1
TMEM16A
Endothelial cells
Endothelium
Pulmonary hypertension
Language:
English
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Active Targeting Antifungal Drug Delivery Systems: A Trends Report, Market Analysis, and Roadmap to Commercialization

Description:
In this thesis, the potential success of a novel drug delivery system (PDAL DDS) in the current antifungal DDS market was evaluated. Focus was placed …
Year:
2022
Contributor:
Whitely, Cutler B (creator)
Mathiowitz, Edith (Reader)
Schell, Jacquelyn (Reader)
Shukla, Anita (Advisor)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Biotechnology
Nanoparticles
Drug delivery systems
Pharmaceutical industry
United States. Food and Drug Administration
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Advancing an in vivo-relevant three-dimensional neural spheroid model for CNS disease modeling

Description:
Central nervous system disease pathologies are poorly understood in part due to the inability of animal and in vitro models to recapitulate their complexity. It …
Year:
2017
Contributor:
Kramer, Liana (creator)
Hoffman-Kim, Diane (Advisor)
Schell, Jacquelyn (Reader)
Mende, Ulrike (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
tissue engineering
in-vitro
Cerebral ischemia
Neurovascular diseases
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Advancing in vitro models of neuroinflammation: Toward understanding and mitigating innate immune responses

Description:
Advancements in neurotechnology have helped people living with paralysis regain function through brain control of communication interfaces, prostheses, and even restored command of one’s own …
Year:
2021
Contributor:
Atherton, Elaina Hope (creator)
Borton, David (Advisor)
Colvin, Vicki (Reader)
Hoffman-Kim, Diane (Reader)
Shukla, Anita (Reader)
Capadona, Jeffrey (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
three-dimensional culture
Drug delivery systems
calcium imaging
Implantable neural interface
Graph theory
Layer-by-layer
Functional Connectivity
Cerium oxides
Endotoxins
Foreign-body reaction
Neuroimmunology
Oxidative stress
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Age-Associated Arrhythmogenic Substrate and Trigger in a Rabbit Model of Cardiac Aging

Description:
Aging is associated with an increased risk of arrhythmias and sudden cardiac death (SCD). Yet, much remains unknown about the mechanisms that underlie the age-related, …
Year:
2013
Contributor:
Cooper, Leroy Leon (creator)
Koren, g (Director)
Koren, Gideon (Director)
Mende, Ulrike (Reader)
Harrington, Elizabeth (Reader)
Sedivy, John (Reader)
Lakatta, Edward (Reader)
Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:
theses
Subject:
senescence
calcium dynamics
ryanodine receptor
Heart
Arrhythmia
Aging
Calcium
Ryanodine--Receptors
Language:
English
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Alpha-Bungarotoxin as a tool for exploring naturally insensitive ion channels

Description:
In this thesis,alpha-bungarotoxin (Bgtx) was validated as a tool for exploring the function and regulation of three otherwise Bgtx-insensitive ion channels: the first is a …
Year:
2009
Contributor:
Liu, Jing (creator)
Hawrot, Edward (director)
Zimmerman, Anita (reader)
Kauer, Julie (reader)
Bowen, Wayne (reader)
Jacob, Michele (reader)
Brown University. Division of Biology and Medicine. Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:
theses
Subject:
alpha-bungarotoxin
nicotinic receptor
voltage gated potassium channel
GABA type A receptor
Ion channels
Language:
English
Collection:
Biology and Medicine
Theses and Dissertations
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

An Analysis of Online Discussions about Neurosurgery for Obsessive-Compulsive Disorder

Description:
Background: For some patients with severe, treatment-resistant obsessive-compulsive disorder (OCD), neurosurgical interventions may be considered. While a few studies have assessed both patient and provider …
Year:
2021
Contributor:
Hornstein, Samuel (creator)
Rosen, Rochelle (Reader)
Greenberg, Benjamin (Reader)
McLaughlin, Nicole (Advisor)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Biotechnology
Obsessive-compulsive disorder
Neurosciences--Research
Medicine--Research
Online Health
Nervous system--Surgery
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Analysis of Antimicrobial Bacteriophage-Hydrogel Therapies

Description:
n/a
Year:
2022
Contributor:
Kurapati, Sai (creator)
Schell, Jacquelyn (Reader)
Analoui, Mostafa (Reader)
Shukla, Anita (Advisor)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Biotechnology
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Analysis of Polystyrene Microsphere Uptake in Passively Fed Danio rerio Larvae via FT-IR Spectroscopy and Fluorescence-Based Detection

Description:
Microplastic pollution of marine environments is a pressing problem for the health of aquatic ecosystems and for global food supply. Many studies have been done …
Year:
2021
Contributor:
Maxwell, Tyler (creator)
Mathiowitz, Edith (Advisor)
Creton, Robbert (Reader)
Jong, Yong (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Fluorescence microscopy
Zebra danio
Polymeric nanoparticles
FT-IR
Microplastics
Plastic pollution
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Analyzing & Determining the Structure of Penicillin Binding Protein 5 from Enterococcus faecium

Description:
Penicillin Binding Protein 5 (PBP5) is a membrane bound transpeptidase that plays an important role in β-lactam antibiotic resistance in Enterococcus faecium. Normally, β-lactams inhibit …
Year:
2017
Contributor:
Lee, Christopher (creator)
Peti, Wolfgang (Advisor)
Schell, Jacquelyn (Reader)
Mathiowitz, Edith (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
PBPs
Crystallography
High performance liquid chromatography
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Antagonistic effect of aspartate-β-hydroxylase on chemotherapeutics in cholangiocarcinoma

Description:
Bile duct cancer, known as cholangiocarcinoma (CCA), is a rare but highly aggressive cancer with a 3% incident in all gastrointestinal cancers. The only known …
Year:
2019
Contributor:
Cao, Kevin (creator)
Wands, Jack (Advisor)
Huang, Chiung-Kuei (Reader)
Li, Ji Su (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
DNA damage
Bile ducts--Cancer
ASPH
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Items (1-20) out of 189 results