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Items (1-20) out of 87 results

"Brightness" and the Physics of Bioluminescent Light Production and Resonance Energy Transfer

Description:
This recorded lecture introduces students to the quantification of "brightness," ways to quantify and compare bioluminescent and fluorescent proteins, and the factors that influence Förster …
Year:
2021
Contributor:
Shaner, Nathan (Author)
Subject:
Bioluminescence
undergraduate education
imaging
fluorescence
Fluorescent Proteins
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

(LMC4f) pAAV-CAG-sbGLuc-dTomato

Description:
  • The NeuroNex Technology Hub and NeuroNex Bioluminescent Constructs Database are supported by the National Science Foundation (NSF) and its Division of Biological Infrastructure under Award …
Year:
2019
Subject:
Bioluminescence
Optogenetics
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Bioluminescent Constructs Database
Full Record

(LMO3) pAAV-hSyn-sbGLuc-VChR1-EYFP

Description:
  • The NeuroNex Technology Hub and NeuroNex Bioluminescent Constructs Database are supported by the National Science Foundation (NSF) and its Division of Biological Infrastructure under Award …
Year:
2018
Subject:
Bioluminescence
Optogenetics
BL-OG
Coelenterazine
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Bioluminescent Constructs Database
Full Record

A bright new luciferase driven by intravenous and intraperitoneal injection

Description:
BioLuminescent-OptoGenetic molecules for driving and imaging neural activity have a number of advantages in vivo. In this approach, genetically expressed luciferases bind with injected luciferins …
Year:
2019
Contributor:
Friedman, Nina J (Creator)
Murphy, Jeremy (Creator)
Klein, Eric (Creator)
Gomez-Ramirez, Manuel (Creator)
Lambert, Gerard (Creator)
Hochgeschwender, Ute (Creator)
Shaner, Nathan (Creator)
Moore, Christopher I. (Creator)
Subject:
BL-OG
Bioluminescence
Optogenetics
calcium indicator
in vivo
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Available to Brown-affiliated users only
Full Record

A Historical Analysis of the Searchable NeuroNex Database of Bioluminescent Molecules: The Annual Biomedical Research Conference for Minority Students (ABRCMS) Presentation Poster and Pre-Recorded Link

Description:
As bioluminescence becomes increasingly significant to imaging and manipulating neurons in the brain, there presents a need for a database that can concisely present bioluminescent …
Year:
2020
Contributor:
Louis, Priscilla (Author)
Bartholomew, Brazil (Author)
MacIntyre, Cameron (Author)
van der Merwe, Rochelle (Author)
Roberts, Mia (Author)
Allen, Justine (Author)
Friedman, Nina (Author)
Moore, Christopher (Author)
Subject:
Bioluminescence
Database
Luciferase
Historical analysis
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

A multifunctional bioluminescent calcium indicator

Description:
We developed a bioluminescent Ca2+ indicator, Lumicampsin (LMC) that employs a split, mutated Gaussia luciferase (sbGluc) with a CaM-M13 calcium sensing moiety introduced between the …
Year:
2018
Contributor:
Pal, Akash (Creator)
Medendorp, William E. (Creator)
Zaldi, Zohair (Creator)
Prakash, Mansi (Creator)
Lipscombe, Diane (Creator)
Moore, Christopher I. (Creator)
Subject:
Bioluminescence
lumicampsin
Optogenetics
calcium indicator
LMC
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Available to Brown-affiliated users only
Full Record

Bioluminescence Activity Placemat

Description:
This double-sided placemat contains activities for students to complete as they learn about the creatures that produce bioluminescence and the differences between bioluminescence, fluorescence, and …
Year:
2019
Contributor:
Berger-Gutierrez, Rebecca (Creator)
Salem, Zara (Creator)
Salem, Halle (Creator)
Khan, Raisa (Creator)
Subject:
Broader Impacts
Bioluminescence
education
fluorescence
phosphorescence
outreach
Collection:
Open Educational Resources (OER) and Research Impacts
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Full Record

Bioluminescence driven optogenetics for investigating functional synaptic communication

Description:
In BioLuminescent driven OptoGenetics (BL-OG) a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. When light emitter …
Year:
2017
Contributor:
Prakash, Mansi (Creator)
St. Laurent, Robyn (Creator)
Pal, Akash (Creator)
Connors, Barry W. (Creator)
Lipscombe, Diane (Creator)
Kauer, Julie A. (Creator)
Moore, Christopher I. (Creator)
Hochgeschwender, Ute (Creator)
Subject:
BL-OG
Bioluminescence
Optogenetics
interluminescence
coelenterazine
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Available to Brown-affiliated users only
Full Record

Bioluminescence driven optogenetics for investigating functional synaptic communication across co-cultured neuronal networks on multi-electrode arrays

Description:
In BioLuminescent driven OptoGenetics (BL-OG) a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. When light emitter …
Year:
2018
Contributor:
Prakash, Mansi (Creator)
St. Laurent, Robyn (Creator)
Pal, Akash (Creator)
Bhaga, Yuvraj (Creator)
Björefeldt, Andreas (Creator)
Connors, Barry W. (Creator)
Lipscombe, Diane (Creator)
Kauer, Julie A. (Creator)
Moore, Christopher I. (Creator)
Hochgeschwender, Ute (Creator)
Subject:
BL-OG
Bioluminescence
coelenterazine
Optogenetics
CTZ
interluminescence
multi-electrode array
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Available to Brown-affiliated users only
Full Record

Bioluminescence imaged using BLmini v2.0 in an anesthetized wild-type animal with the cortical application of luciferin (hCTZ) from Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain

Description:
Bioluminescence imaged using BLmini v2.0 in an anesthetized wild-type animal with the cortical application of luciferin (hCTZ). Bioluminescent calcium indicator was expressed via intracortical injection …
Year:
2024
Contributor:
Celinskis, Dmitrijs (Creator)
Subject:
Brain
miniscope
bioluminescence (BL)
BLmini2
hCTZ
intracortical
CaBLAM
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Brown University Open Data Collection
Full Record

Bioluminescence imaged using BLmini v2.0 in an anesthetized wild-type animal with the second administration and cortical application of luciferin (hCTZ) from Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain

Description:
Bioluminescence imaged using BLmini v2.0 in an anesthetized wild-type animal with the cortical application of luciferin (hCTZ). Bioluminescent calcium indicator was expressed via intracortical injection …
Year:
2024
Contributor:
Celinskis, Dmitrijs (Creator)
Subject:
Brain
miniscope
bioluminescence (BL)
BLmini2
hCTZ
intracortical
CaBLAM
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Brown University Open Data Collection
Full Record

Bioluminescence: Ideal Natural Engineering for Understanding the Dynamics that Create Behavior

Description:
This recorded lecture introduces undergraduate students to the advantages of bioluminescence as an optical reporter of a chemical reaction and its use with optogenetics (BL-OG) …
Year:
2021
Contributor:
Moore, Christopher I. (Author)
Subject:
Neuroscience
BL-OG
Bioluminescence
Behavior
Undergraduate Education
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

Bioluminescent Parchment Tube Worm

Description:
This is a video of a bioluminescent parchment tube worm (Chaetopterus) emitting blue light. The secreted mucus is luminescent.
Year:
2019
Contributor:
Shaner, Nathan C. (Author)
2019 NeuroNex Practicum Class (Author)
Subject:
Bioluminescence
blue light
Chaetopterus
parchment tube worm
Collection:
Brown University Open Data Collection
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Bioluminescent sensing of intracellular calcium at calcium channels

Description:
Bioluminescent sensors of intracellular calcium offer a number of advantages in vitro and in vivo. Calcium-sensing luciferases can be further tethered to specific voltage-gated Ca …
Year:
2019
Contributor:
Koksharov, Mikhail (Creator)
Gratz, Scott (Creator)
O'Connor-Giles, Kate (Creator)
Lipscombe, Diane (Creator)
Moore, Christopher I. (Creator)
Subject:
Bioluminescence
calcium indicator
calcium sensing
calcium channels
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Available to Brown-affiliated users only
Full Record

BL-OG: Bridging Optogenetics and Chemogenetics through Bioluminescence

Description:
This card was created to succinctly communicate the properties and function of bioluminescent-optogenetic (BL-OG) constructs.
Year:
2019
Contributor:
Khan, Raisa (Creator)
Subject:
Broader Impacts
Bioluminescence
education
fluorescence
phosphorescence
outreach
Collection:
Open Educational Resources (OER) and Research Impacts
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Full Record

BLmini can detect bioluminescence dynamics in mouse brain

Description:
In vivo fluorescence miniature microscopy has recently proven a major advance, enabling cellular imaging in freely behaving animals. However, fluorescence imaging suffers from autofluorescence, phototoxicity, …
Year:
2020
Contributor:
Celinskis, Dmitrijs (Creator)
Subject:
Bioluminescence
imaging
microscope
Collection:
Brown University Open Data Collection
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

BRAIN Initiative projects transcend traditional categories promoting inclusion

Description:
Categories serve to reduce complexity and help us to navigate our social environment. At the same time, they can trap individuals in perceived or real …
Year:
2021
Contributor:
Hochgeschwender, Ute (Author)
Allen, Justine J. (Author)
Literman, Krystal (Author)
Shaner, Nathan C. (Author)
Lipscombe, Diane (Author)
Moore, Christopher I. (Author)
Subject:
diversity
STEM education
equity
inclusion
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Building a bioluminescent and optogenetic (BL-OG) learning community through immersive outreach experiences

Description:
The Bioluminescence Hub, a National Science Foundation NeuroNex Technology Hub, is dedicated both to the development of novel bioluminescent and optogenetic tools and to the …
Year:
2019
Contributor:
Literman, Krystal R. (Creator)
Allen, Justine J. (Creator)
Lipscombe, Diane (Creator)
Hochgeschwender, Ute (Creator)
Shaner, Nathan C. (Creator)
Moore, Christopher I. (Creator)
Subject:
education
Optogenetics
STEM outreach
bioluminescece
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
NeuroNex Educational and Engagement Materials
Full Record

Calcium — Not Too Little and Not Too Much

Description:
This recorded lecture introduces undergraduate students to calcium as a ubiquitous second messenger and a proxy for cellular activity. Students learn why calcium is unique, …
Year:
2021
Contributor:
Lipscombe, Diane (Author)
Subject:
undergraduate education
calcium
Action Potentials
Cell Signalling
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

Cell-Target Specific BioLuminescent-OptoGenetic Synaptic Signaling in vivo: BioLumInescent Trans-Emitters (B-LiTE)

Description:
Fluorescence-based optogenetic tools are powerful methods for dissecting cell-type specific circuit dynamics in the nervous system. These tools, however, rely on external, generic modification of …
Year:
2019
Contributor:
Murphy, Jeremy W. (Creator)
Friedman, Nina (Creator)
Prakash, Mansi (Creator)
Celinskis, Dmitrijs (Creator)
St. Laurent, Robyn (Creator)
Lipscombe, Diane (Creator)
Shaner, Nathan (Creator)
Hochgeschwender, Ute (Creator)
Moore, Christopher I. (Creator)
Subject:
BL-OG
Bioluminescence
Optogenetics
interluminescence
in vivo
optical synapse
POMC-sbgluc
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Available to Brown-affiliated users only
Full Record

Items (1-20) out of 87 results