Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
This thesis is divided into two parts. The first part of this thesis, including chapters 1-3, examines the role of the protein Muscle specific kinase …
Adult Hippocampal Neurogenesis (AHN) is the process through which newborn neurons are born and integrated into brain circuitry. Patients with conditions like Alzheimer’s Disease (AD) …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a progressive, rapid loss of motor function. Within 3-5 years, a loss of motor function …
The bone morphogenetic protein (BMP) signaling pathway is an essential regulator of developmental and cellular processes. Secreted ligands initiate BMP signaling by binding to a …
The neuromuscular junction (NMJ) is required for muscle excitation, and its dysfunction is thought to contribute to deficits observed in sarcopenia and neuromuscular disease. The …
