Cytokinesis is an essential process for the proliferation of eukaryotic species. However, our knowledge of how a eukaryotic cell accomplishes cytokinesis is relegated to a …
As a chemically reactive species, DNA can be modified by endogenous and exogenous agents such as lipid peroxidation products, UV radiation, and reactive oxygen species …
As a chemically reactive species, DNA can be modified by endogenous and exogenous agents such as lipid peroxidation products, UV radiation, and reactive oxygen species …
As a chemically reactive species, DNA can be modified by endogenous and exogenous agents such as lipid peroxidation products, UV radiation, and reactive oxygen species …
As a chemically reactive species, DNA can be modified by endogenous and exogenous agents such as lipid peroxidation products, UV radiation, and reactive oxygen species …
DNA damage is the primary molecular mechanism responsible for cancer and aging. DNA lesions can derive from oxidation, deamination, or alkylation of the nucleobases. If …
Repair of damaged DNA plays a crucial role in maintaining genomic integrity and normal cell function. The base excision repair (BER) pathway is primarily responsible …
Regions of repetitive DNA, in particular trinucleotide repeats, are common throughout the human genome and are of interest as a source of genomic instability. DNA …
Cell division is fundamental to life. As more divergent organisms become tractable to genetic manipulation, we have discovered that the molecular mechanisms that govern cell …
Nearly half of the human genome is comprised of mobile genetic elements known as transposons. Most transposons in humans can no longer create new copies …
Cytoplasmic mRNA localization is understood as an important biological strategy for establishing cell and developmental polarity in a variety of organisms and cell types. In …
Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active autonomously replicating retrotransposon in humans, comprising approximately 17% of the genome [1]. While normally …
Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active autonomously replicating retrotransposon in humans, comprising approximately 17% of the genome [1]. While normally …
Cellular senescence is a state of permanent cell cycle arrest that plays a major role in damage response, tumor suppression, and aging. Although many prominent …
T cells recognize antigens via T cell receptors (TCR), initiating an intracellular signal transduction cascade. Tyrosine is one of the main amino acids that is …
T cells recognize antigens via T cell receptors (TCR), initiating an intracellular signal transduction cascade. Tyrosine is one of the main amino acids that is …
Repair of damaged DNA is indispensable for not only cellular, but also organismal survival. Nucleobase lesions, which arise from endogenous or exogenous sources of damage, …
Despite being essential for organismal survival, genomic DNA is chemically reactive and susceptible to modification to generate mutagenic and/or cytotoxic lesions. These lesions include oxidation, …
