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Items (1-13) out of 13 results

A Perspective of DNA glycosylase Enzyme on Base Excision Repair

Description:
As a chemically reactive species, DNA can be modified by endogenous and exogenous agents such as lipid peroxidation products, UV radiation, and reactive oxygen species …
Year:
2020
Contributor:
Gonzalez-Dumeng, Christian (Author)
Sutton, Treshaun (Author)
Caffrey, Paul (Author)
Delaney, Sarah (Author)
Leadership Alliance Summer Research Early Identification Program (SR-EIP) (research program)
Subject:
Enzymes
Biochemistry
DNA repair
Collection:
The Leadership Alliance Digital Library
Available to Brown-affiliated users only
Full Record

A Perspective of DNA glycosylase Enzyme on Base Excision Repair

Description:
As a chemically reactive species, DNA can be modified by endogenous and exogenous agents such as lipid peroxidation products, UV radiation, and reactive oxygen species …
Year:
2020
Contributor:
Gonzalez-Dumeng, Christian (Author)
Sutton, Treshaun (Author)
Caffrey, Paul (Author)
Delaney, Sarah (Author)
Leadership Alliance Summer Research Early Identification Program (SR-EIP) (research program)
Subject:
Enzymes
Biochemistry
DNA repair
Collection:
The Leadership Alliance Digital Library
Available to Brown-affiliated users only
Full Record

A Perspective of DNA glycosylase Enzyme on Base Excision Repair

Description:
As a chemically reactive species, DNA can be modified by endogenous and exogenous agents such as lipid peroxidation products, UV radiation, and reactive oxygen species …
Year:
2020
Contributor:
Gonzalez-Dumeng, Christian (Author)
Sutton, Treshaun (Author)
Caffrey, Paul (Author)
Delaney, Sarah (Author)
Leadership Alliance Summer Research Early Identification Program (SR-EIP) (research program)
Subject:
Enzymes
Biochemistry
DNA repair
Collection:
The Leadership Alliance Digital Library
Available to Brown-affiliated users only
Full Record

A Perspective of DNA glycosylase Enzyme on Base Excision Repair

Description:
As a chemically reactive species, DNA can be modified by endogenous and exogenous agents such as lipid peroxidation products, UV radiation, and reactive oxygen species …
Year:
2020
Contributor:
Gonzalez-Dumeng, Christian (Author)
Sutton, Treshaun (Author)
Caffrey, Paul (Author)
Delaney, Sarah (Author)
Leadership Alliance Summer Research Early Identification Program (SR-EIP) (research program)
Subject:
Enzymes
Biochemistry
DNA repair
Collection:
The Leadership Alliance Digital Library
Available to Brown-affiliated users only
Full Record

Base Excision Repair: Kinetics in Context

Description:
DNA damage is the primary molecular mechanism responsible for cancer and aging. DNA lesions can derive from oxidation, deamination, or alkylation of the nucleobases. If …
Year:
2017
Contributor:
Bilotti, Katharina (creator)
Delaney, Sarah (Advisor)
Salomon, Arthur (Reader)
Cane, David (Reader)
Brown University. Department of Chemistry (sponsor)
Genre:
theses
Subject:
DNA
Biochemistry
Chemistry
DNA repair
Collection:
Chemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Challenges for Base Excision Repair Enzymes: Acquiring Access to Damaged DNA in Chromatin

Description:
Repair of damaged DNA plays a crucial role in maintaining genomic integrity and normal cell function. The base excision repair (BER) pathway is primarily responsible …
Year:
2020
Contributor:
Li, Chuxuan (creator)
Delaney, Sarah (Advisor)
Seto, Christopher (Reader)
Salomon, Arthur (Reader)
Brown University. Department of Chemistry (sponsor)
Genre:
theses
Subject:
Biochemistry
Chemistry
DNA repair
DNA damage
Histones
Collection:
Chemistry
Theses and Dissertations
Full Record

Characterizing DNA secondary structure of hairpin-containing intermediates of the base excision repair pathway

Description:
Regions of repetitive DNA, in particular trinucleotide repeats, are common throughout the human genome and are of interest as a source of genomic instability. DNA …
Year:
2015
Contributor:
Bolton, Elizabeth (creator)
Delaney, Sarah (advisor)
Brown University. Undergraduate Teaching and Research Award (research program)
Genre:
posters
Subject:
DNA
Biochemistry
Collection:
Summer Research Symposium
Full Record

Insights into Maternal mRNA Localization: Characterization of a New Cytoplasmic RNA Granule

Description:
Cytoplasmic mRNA localization is understood as an important biological strategy for establishing cell and developmental polarity in a variety of organisms and cell types. In …
Year:
2019
Contributor:
Neil, Christopher Richer (creator)
Johnson, Mark (Reader)
Larschan, Erica (Reader)
Fallon, Justin (Reader)
Mowry, Kimberly (Advisor)
Marlow, Florence (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Molecular biology
Biochemistry
RNA
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Investigating the Line-1 ORF2 C-Terminal Domain

Description:
Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active autonomously replicating retrotransposon in humans, comprising approximately 17% of the genome [1]. While normally …
Year:
2020
Contributor:
Ashley E Battenberg (creator)
Gerwald Jogl (advisor)
Brown University. Karen T. Romer Undergraduate Teaching and Research Awards (research program)
Genre:
posters
Subject:
Proteins
Homology (Biology)
Aging
Molecular biology
Computational biology
Biochemistry
Zinc-finger proteins
Proteins--Analysis
Collection:
Summer Research Symposium
Full Record

Investigating the Line-1 ORF2 C-Terminal Domain

Description:
Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active autonomously replicating retrotransposon in humans, comprising approximately 17% of the genome [1]. While normally …
Year:
2020
Contributor:
Ashley E Battenberg (creator)
Gerwald Jogl (advisor)
Brown University. Karen T. Romer Undergraduate Teaching and Research Awards (research program)
Genre:
posters
Subject:
Proteins
Homology (Biology)
Aging
Molecular biology
Computational biology
Biochemistry
Zinc-finger proteins
Proteins--Analysis
Collection:
Summer Research Symposium
Full Record

Stability and location of mutant proteins in bacterial cells

Description:
Evolution by selection begins at the molecular level within the cell: a series of mutations occur that are able to become fixed in the population, …
Year:
2015
Contributor:
Spangle, Dylan (creator)
Weinreich, Daniel (advisor)
Brown University. Undergraduate Teaching and Research Award (research program)
Genre:
posters
Subject:
Drug resistance in microorganisms
Beta-lactamases
Biochemistry
Collection:
Summer Research Symposium
Full Record

The Initiation of Base Excision Repair in Nucleosome Core Particles

Description:
Despite being essential for organismal survival, genomic DNA is chemically reactive and susceptible to modification to generate mutagenic and/or cytotoxic lesions. These lesions include oxidation, …
Year:
2019
Contributor:
Kennedy, Erin Elizabeth (creator)
Delaney, Sarah (Advisor)
Freiman, Richard (Reader)
Deaconescu, Alexandra (Reader)
Morrow, Eric (Reader)
Beuning, Penny (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Molecular biology
Chromatin
Biochemistry
DNA repair
Enzymes
chemical biology
DNA damage
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Understanding aging by investigating genes, diet, and biochemistry in Drosophila

Description:
To explore the problem of aging, we used fruit flies to model the physiological effects of genes and environment. The biochemistry of Drosophila melanogaster can …
Year:
2014
Contributor:
Devlin, Tyler (creator)
Howard Hughes Medical Institute (research program)
Rand, David (advisor)
Genre:
posters
Subject:
Aging
Biochemistry
Drosophila
Gene
Diet
Triacylglycerol
Collection:
Summer Research Symposium
Full Record
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Items (1-13) out of 13 results