The efficacy of clinical trials hinges significantly on the process of patient selection, often marred by resource-intensive procedures and inherent inefficiencies. While randomized controlled trials …
Hypoxic ischemic encephalopathy (HIE) occurs in 2-9 per 1,000 live births, with 60% of those cases ending in morbidity or long-term disability. HIE is caused …
Background: Anesthesiology, a critical field in medicine, heavily relies on evidence-based practices, which are often derived from clinical trials. Understanding the scope and focus of …
Introduction Colonoscopy is instrumental in early detection and prevention of colorectal cancer. Nonetheless, the procedure can still fail to identify early and advanced lesions, leading …
Author: Pangborn, Joshua, A Institution: Brown University Title: Clinical implementation of a new technology: provider perspectives and perceived effects of an incentive spirometer patient reminder …
Background: Randomized clinical trials (RCTs) are considered the gold standard approach for assessing the comparative effectiveness of medical interventions. Given the importance of RCTs for …
In data analysis, simultaneously performing multiple hypothesis tests will increase error rates. The multiple testing problem is common across different field of studies including microarray …
As participants in federally funded studies, prisoners in the United States are afforded special protections beyond those governing traditional human subjects research. While these rules …
Abstract of “Evaluating the utilization and effectiveness of incentive spirometry” by Adam E. M. Eltorai, Ph.D., Brown University, May 2018 Background: Incentive spirometers (IS) were …
Clinical trials of Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD) have shown promise. DBS consists of the surgical placement of electrodes to electrically stimulate …
Heterogeneous treatment effect estimation is commonly performed by exploring treatment covariate interactions in regression models or by performing pre-specified subgroup analyses using data from randomized …
Introduction: Pharmacotherapy development for alcohol use disorder (AUD) treatment is a long and challenging process. One of the challenges in early stage clinical research for …
BACKGROUND: Race-based disparities in gynecologic oncology (GYN-ONC) clinical trials are well-documented. In 2012, the FDA introduced the Safety and Innovation Act (FDASIA) to improve the …
