The bone morphogenetic protein (BMP) signaling pathway is an essential regulator of developmental and cellular processes. Secreted ligands initiate BMP signaling by binding to a …
The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA. Here, …
Genetically determined, fixed action pattern behaviors offer a useful model for studying how developmental gene expression programs lay down a neuroanatomical architecture that underlies these …
Transposable elements (TEs) are parasitic mobile sequences of DNA that can proliferate throughout the genome by replicating and reinserting themselves into new regions of DNA. …
Effective treatments of alcohol use disorder (AUD) have remained elusive largely because the underlying mechanisms of this devastating disorder are poorly understood. Fruit flies form …
Transposable elements (TEs) are parasitic mobile sequences of DNA that proliferate throughout host genomes by replicating and reinserting themselves into new regions of DNA. This …
ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
Understanding individuals’ choice to self-administer drugs of abuse is an ongoing endeavor. Drosophila is an excellent model to investigate this due to the impressive temporal …
A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This modification …
To explore the problem of aging, we used fruit flies to model the physiological effects of genes and environment. The biochemistry of Drosophila melanogaster can …
In all organisms, gene regulation is crucial for proper cell function and development. Dosage compensation is one such mechanism of gene regulation. In Drosophila melanogaster, …
Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
Alcohol Use Disorder is a chronic relapse disorder driven by the persistence of cravings, despite its deleterious social and health ramifications. The development of adequate …
The brain is composed of discrete units called neurons. Neurons communicate with each other and form functional circuits, the fundamental computational units of the nervous …
Supplemental Tables 1-10 associated with the manuscript "The Genetic Architecture of Robustness for Flight Performance in Drosophila" (in prep, May 2020) and the dissertation: "The …
Supplemental File 3 associated with the manuscript "Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila" (in prep, May 2020) and …
Supplemental Tables 1-18 associated with the manuscript "Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila" (in prep, May 2020) and …
Supplemental File 1 associated with the manuscript "FreeClimber: Automated High Throughput Quantification of Climbing Performance in Drosophila, with Examples from Mitonuclear Genotypes" (in prep, May …
Supplemental File 2 associated with the manuscript "The Genetic Architecture of Robustness for Flight Performance in Drosophila" (in prep, May 2020) and the dissertation: "The …
Supplemental File 1 associated with the manuscript "Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila" (in prep, May 2020) and …