Cytokinesis is an essential process for the proliferation of eukaryotic species. However, our knowledge of how a eukaryotic cell accomplishes cytokinesis is relegated to a …
Opsins are members of the rhodopsin G-protein coupled receptors (GPCRs) family that mediate phototransduction in both invertebrates and vertebrates. More specifically, humans have nine types …
Cell division is fundamental to life. As more divergent organisms become tractable to genetic manipulation, we have discovered that the molecular mechanisms that govern cell …
Normal brain development, involving neuronal migration, polarity and differentiation, requires synaptic trafficking of essential cargo. These cargo are primarily transported on microtubules (MTs), which play …
Motor neurons are a class of post-mitotic cells expected to survive for the duration of the human lifetime. While other cells routinely undergo programmed cell …
Biological systems must regulate complex gene transcriptional programs to mediate phenotypic response to diverse stimuli. Control of gene expression requires specific DNA sequence patterns called …
Fragile X syndrome, a leading cause of autism and the most common form of inherited intellectual disability, results from the loss of Fragile X mental …
Embryonic stem cells (ESCs) are found early in the developing embryo and from this initial population, all cells in the body are eventually derived. A …
Common fragile sites (CFS) in DNA are locations of frequent chromosomal breakage, and are often hot spots for chromosomal rearrangements – a common feature of …
Mfd is a transcriptional-repair coupling factor (TRCF) that is involved in a variety of cellular processes involving stalled or paused RNA polymerases, such as transcription …
Cytoplasmic mRNA localization is understood as an important biological strategy for establishing cell and developmental polarity in a variety of organisms and cell types. In …
Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active autonomously replicating retrotransposon in humans, comprising approximately 17% of the genome [1]. While normally …
Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active autonomously replicating retrotransposon in humans, comprising approximately 17% of the genome [1]. While normally …
This UTRA project studied RNA localization in Xenopus laevis oocytes, which is facilitated by the formation of specific cytoplasmic ribonucleoprotein (RNP) granules termed Localization-bodies (L-bodies). …
Cellular senescence is a state of permanent cell cycle arrest that plays a major role in damage response, tumor suppression, and aging. Although many prominent …
The discipline of protein evolution aims to understand the principles and driving forces whereby new protein-coding genes, protein structures, and biological functions emerge due to …
Tissue remodeling occurring up to years after myocardial infarction can promote initiation and propagation of potentially lethal cardiac arrhythmias. The wound healing process and electrophysiological …
Infections borne from the implantation of medical devices has continued to be a global health concern. Bacteria are capable of binding to the surfaces of …
Single-molecule approaches enable us to follow the movement, interactions and conformational dynamics of individual molecules in real-time, thus providing novel insights in complex biochemical systems …
