This thesis highlights our advances across many disciplines developing a fully implantable, low power, broadband, and wireless neural recording platform for use in persons with …
Surgical site infections (SSIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) are one of the leading causes of avoidable patient complication (World Health Organization, 2018; Chiang, …
Siemens Healthineers’ DirectDensity algorithm was calibrated and validated for high Z materials using three distinct methods: Monte Carlo simulation, a novel phantom study, and analysis …
Cells of the central nervous system create intricate, three-dimensional networks in vivo that are compromised when cultured on traditional two-dimensional surfaces. As a result, 2D …
Over time, more neurodegenerative disorder-linked mutations are being discovered, with more components of RNA/RNP granules containing disordered regions/domains and exhibiting the ability to undergo liquid-liquid …
Ischemic heart disease is the leading cause of death globally, which takes more than 17.7 million lives every year (WHO, 2018), yet current treatments and …
The placenta plays a crucial role during pregnancy, yet it remains one of the least understood human organs. Trophoblast cells comprise the placenta with functions …
Objective: The objective of this study was to create a convolutional neural network (CNN) capable of predicting the size, elastic modulus, and the location of …
Triple negative breast cancer (TNBC) is a heterogenous form of breast cancer known for its poor prognoses and lack of reliable treatment options due to …
Stem cells have shown great promise for the treatment of human disease. However, stem cell therapies are limited by heterogeneous differentiation. As a result, researchers …
Stroke is one of the leading causes of disability in the United States. Approximately 80% of individuals affected by stroke have a resulting movement disorder …
Mechanical properties of biological cells have been shown to correlate with their biomolecular state and function, and therefore methods to measure these properties at scale …
The research presented in this thesis aims to advance our understanding of cellular behavior in physiologically relevant environments composed of single cues or multiple cues. …
Tribology is the study of friction, wear, and lubrication. For the past several decades, the engineering principles of tribology have been used in attempts to …
Objective: Create a wheelchair- jogger hybrid that is more stable and more maneuverable than frequently sold wheelchair models and wheelchairs available in hospitals. This hybrid …
Microsphere drug delivery systems still face many hurdles specific to gastrointestinal uptake. Human physiological components are difficult to properly emulate and test without the usage …
While many strides have been made in the field of tissue engineering since its inception, the need for a physiologically relevant biological substitute remains unmet. …
In my dissertation, I present solutions, best practices, and lessons learned for tailoring implantable neural devices to a psychiatric population toward enabling neural biomarker identification …
Rich and fast somatosensory feedback is a necessary condition for fluid motor function. People with degraded proprioception, whether it is due to neurological insult, paralysis, …