The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol β) …
Infections caused by antibiotic-resistant bacteria present an ever-growing challenge to physicians. The growing antibiotic resistance among pathogenic bacteria has caused the Centers for Disease Control …
DNA damage is the primary molecular mechanism responsible for cancer and aging. DNA lesions can derive from oxidation, deamination, or alkylation of the nucleobases. If …
The majority of biologically important carbohydrates exist as polysaccharides or as complex glycoconjugates in which oligosaccharides are connected to peptides, proteins, or fatty acids. First …
The basal T cell signaling is important in the T cells maturation and differentiation. The kinase-phosphatase pair Csk and CD45 regulate the basal signaling by …
The reactivity and structure determination of various organolithium reagents are described. First of all, we present the development of 13C enriched internal reference system for …
An oxidized lesion of guanine that is detected following exposure of DNA to several oxidizing agents is 8-oxo-7,8-dihydro-guanine (8-oxoG). Studies done in vitro show that …