Host-microbe interactions heavily influence both fitness and disease. Traditionally, research on host-microbe interactions focused on the concept that microbes only contribute to pathogenesis. However, recent …
Candida albicans causes the majority of invasive candidiasis in immunocompromised adults while Candida parapsilosis is a leading cause of neonatal candidiasis. While considerable study has …
The rise in antibiotic resistance and the importance of the mammalian microbiome necessitates new models that could expedite and streamline the study of host-microbiome interactions …
Breast cancer is the second most frequently diagnosed cancer and the second leading cause of cancer death in U.S. women. The studies presented in this …
This dissertation attempted to elucidate the role of - and -defensins in JCPyV infection, determine a mechanism of action of HD5-mediated JCPyV neutralization, and to …
Pollution, the release of chemicals into the environment, is the result of current and historic industrial and waste management practices and a range of human …
Objective: There are 240 million cases of malaria each year, making it one of the most endemic diseases in modern history. However, not substantial preventative …
Helicobacter pylori infection is associated with severe chronic inflammation, however the host immune response is unable to clear the bacterium. Thymus derived lymphocyte populations such …
BACKGROUND: Food insecurity continues to impact low-income elderly Americans. The Commodity Supplemental Food Program (CSFP) is a federal food-box program targeted specifically to this population. …
Antibiotics are critical to modern medicine and allow clinicians to combat pathogenic bacteria. Resistance to these important drugs is hindering our ability to treat many …
Neutrophils are critical to the innate immune system's defense against pathogen invasion. In response to insult, neutrophils are recruited in large quantities to employ their …
The etiologies for adverse pregnancy outcomes such as recurrent spontaneous abortion, preeclampsia, preterm birth and gestational diabetes mellitus (GDM) are multi-factorial and remain poorly understood. …
GSK-3 is a serine/threonine kinase overexpressed in multiple tumor types and implicated in several oncogenic processes. GSK-3 inhibitor (GSK-3i) elraglusib (elra) has shown promising preclinical …
Abstract of Inhibition of HDAC7 Using RNAi As an Epigenetic- Based Therapy in Targeting Malignancies, by Ola Hassan, Ph.D., Brown University, May 2024. Class IIa …
Synthesis and degradation of the extracellular matrix (ECM) are important for tissue development, morphogenesis, repair, and remodeling. Multiple proteinases are involved in the degradation of …
The studies presented in this thesis investigated innate immune events in the liver during acute infection with murine cytomegalovirus (MCMV). While many responses that occur …
Invasive fungal infections are emerging as a significant cause of morbidity and mortality, especially among the increasing immunosuppressed patient populations. Transition to a filamentous hyphal …
The mammalian Target of Rapamycin (mTOR) is a Ser/Thr kinase that regulates cell growth through its control of cell cycle progression, translation, ribosome biogenesis and …
Gliomas are a family of extremely aggressive brain cancers, which, despite current treatment options, have poor prognoses. There are distinct subtypes of gliomas, and accurately …