The human genome exhibits a rich structure resulting from a long history of genomic changes, including single base-pair mutations and larger scale rearrangements such as …
Variation in genomes occurs in many forms, from single nucleotide changes to gains and losses of entire chromosomes. Large-scale rearrangements, called structural variants (SVs), are …
Cancer is a disease resulting from genomic mutations that occur during an individual's lifetime and cause the uncontrolled growth of a collection of cells into …
Cancer is caused largely by the accumulation of somatic mutations throughout an individual's life. Recent advances in next generation sequencing (NGS) enable measurement of somatic …
Recent improvements in DNA sequencing technology have opened new paths towards understanding cancer biology and designing personalized cancer treatments. Cancer is caused in part by …