Abstract of Inhibition of HDAC7 Using RNAi As an Epigenetic- Based Therapy in Targeting Malignancies, by Ola Hassan, Ph.D., Brown University, May 2024. Class IIa …
Purpose Previous studies found that higher citrus consumption was associated with increased risks of malignant melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). …
Cancer is characterized by heterogeneity at multiple scales, with implications for diagnosis, prognosis, and treatment. Major advances in genomics have led to a proliferation of …
Checkpoint blockade therapy, which targets conserved negative regulators of immune cell activation that act as “checkpoint molecules” that govern the balance between inhibition and hyperactivation …
The field of computer assisted radiology has recently seen an explosion of novel techniques that have been made possible due to advancements in computer algorithms. …
Ovarian cancer is the most lethal gynecological cancer largely due to its late detection after metastasis has occurred. Stromal cells (SCs) promote cancer cell growth …
With the increased availability of mobile technology, there exists and opportunity for electronic-based patient education programs to help start conversations between providers and patients in …
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer death in the United States. Chronic …
Anxiety during radiation therapy (RT) can negatively impact the effectiveness of treatment and can lead to poorer health outcomes for cancer patients. Currently, the prevalent …
This dissertation demonstrates, in multiple ways, that nanotechnology can be used to engineer effective solutions. This dissertation employs the colloidal route for synthesis of elemental …
The objective of this thesis was to study the potential of using nanometer structured selenium for various biomedical applications. Experimental results showed much promise for …
Cells are rich in a variety of diagnostic information, from morphology to nucleic acid, protein, and metabolite composition. Cells possess more data than any other …
Cellular immunotherapy is a rapidly developing field in cancer research that uses the immune system of both the recipients and the donors to attack tumor …
Background: The TP53 rs1042522 (Arg72Pro) polymorphism is one of the most commonly investigated genetic variants in cancer epidemiology. We conducted a systematic review and meta-analysis …
Abstract of Profiling Cancer Cell Invasion and Plasticity in Biomimetic Materials, by Amanda S. Khoo, Ph.D., Brown University, February 2022 Cancer metastasis is a major …
The tumor microenvironment is characterized by an acidic pH which confers the expression of more malignant phenotypes in cancer cells such as increased proliferation, migration, …
Chitinase 3-like-1 (CHI3L1), a pleiotropic secretory molecule, plays essential roles in the pathogenesis of a variety of malignancies by boosting tumor cell proliferation, migration, epithelial-to-mesenchymal …
Abstract of Sigma-2 Receptor-Mediated Changes in Metabolism and Calcium Signaling, Degree ScM, Brown University, May 2019 Sigma receptors are a pharmacologically distinct family of membrane-bound …
This dissertation examines the constitutive relation of gender and performance to knowledge production in the genetic sciences in twentieth and twenty-first century US. In recent …