Defining diverse roles of a single transcription factor on the cellular level is key to understanding its role in the context of an organism. However, …
Biological systems must regulate complex gene transcriptional programs to mediate phenotypic response to diverse stimuli. Control of gene expression requires specific DNA sequence patterns called …
Reciprocal recombinant F2 populations of the fruitfly were created and analyzed using a pooled whole-genome sequencing approach to investigate the effects of divergent mitochondrial DNA …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of motor neurons that affects at least 30,000 people in the United States at any one time …
Resistance to starvation is a classical complex trait, where varying genetic and environmental landscapes can greatly modify an animal’s ability to cope. In this study, …
Cell-cell communication is crucial for the function of an organism. In Drosophila, motor neurons signal from the ventral nerve cord (VNC) to muscles while surrounding …
Neurodegenerative diseases are a group of etiologically heterogeneous diseases characterized by the loss of a vulnerable subset of neurons. Despite this heterogeneity in etiology, TDP-43 …