Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
Reversible protein phosphorylation plays a pivotal role in the regulation of cellular signaling pathways. Current approaches in phosphoproteomics focus on analysis of the global phosphoproteome …
A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This modification …
An exceptional group of aquatic invertebrates makes up Class Bdelloidea. Bdelloid rotifers are the only group of ancient asexual animals known. A second distinction that …
The endoderm germ layer gives rise to the epithelial lining of the respiratory and digestive tracts and their associated organs. Gastrulation and formation of the …
In eukaryotic cells, informational recoding and RNA interference (RNAi) proceed through structurally diverse double-stranded (ds) RNA molecules. Informational recoding of RNA by the catalytic deamination …
In this thesis we provide evidence that the FAIRE method can reveal interesting and relevant changes in genome-wide chromatin organization as cells undergo replicative senescence, …
The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA. Here, …
In sexual reproduction, fusion of haploid sperm and egg cells (gametes) are required to produce a unique diploid individual that represents the next generation. Despite …
Inhibitory interneurons are essential for normal cortical function. They prevent seizures, regulate temporal and spatial coding, and generate oscillations and synchrony in pyramidal cells. The …
About 7.1% of Americans older than 18 have been reported to abuse alcohol. Chronic alcoholics are more susceptible to infections. In this regard, higher incidences …
Polycomb Group (PcG) epigenetic regulators are important but not well-understood components of cellular senescence. EZH2, a PcG histone H3 lysine-27 methyltransferase, is repressed in senescent …
Fragile X syndrome, a leading cause of autism and the most common form of inherited intellectual disability, results from the loss of Fragile X mental …
The insulin (IR) and insulin-like growth factor receptors (IGF-IR) are critical mediators of growth, development and survival. Given their immense biological significance, a complex system …
Vital to the function of any organ system is the proper specification and distribution of cell types during development. This is especially true for the …
Mendelian inheritance relies on the segregation of allelic pairs during the production of gametes, allowing equal exposure of all genotypes to the forces of natural …