There has been mounting concern over the health hazards of per- and polyfluoroalkyl substances (PFAS), which has spread beyond the scientific community to federal regulators, …
Venous thromboembolism (VTE) is the third most common cardiovascular disorder in the United States, and the most preventable cause of death in hospitals. Despite recent …
High Grade Serous Carcinoma (HGSC) is the deadliest form of ovarian cancer among women and causes the most deaths of gynaecological cancers overall (Tudrej, Patrycja …
Sigma receptors are a pharmacologically defined class of intracellular orphan receptors that bind a variety of psychotropic agents. The endogenous function of the sigma-2 receptor …
The GH18 gene family includes true chitinases (Cs) and chitinase-like proteins (CLPs). Chitinase 3-like-1 (CHI3L1) is a prototypic CLP and elevated CHI3L1 expression has been …
KMT2A-translocations are seen in 5-10% of patients with leukemia, but it is present in approximately 50% of pediatric AML diagnoses. Acute leukemias carrying chromosomal translocations …
Abstract of CHARACTERIZING SEEDING DENSITY AS A MECHANISM OF CHEMOTHERAPY RESISTANCE IN CANCER CELLS, by Ujwal Punyamurtula, ScM, Brown University, May, 2022. While the 50% …
Cancer is a disease resulting from genomic mutations that occur during an individual's lifetime and cause the uncontrolled growth of a collection of cells into …
This dissertation focuses on the development of new drug delivery platforms using carbon nanotubes. Two nanotube systems, namely single walled carbon nanotubes (SWNTs) and multi-walled …
This study describes the development of bicarbonate modified Gellan and PEG hydrogels for the purpose of regulating the pH of its surrounding solution. These hydrogels …
Human glioblastomas develop within the brain parenchyma in which there is continuous interaction of glioma cells with axon fibers, glial cells and endothelial cells. This …
Anesthesia, in particular opioids, may have significant clinical implications in cancer. This effect cannot be generalized across different cancer types, and this likely holds true …
The experiences of cisgender sexual minority and gender minority patients with cancer are different. Previous research has demonstrated that gender minority people are less likely …
Breast cancer is the second most frequently diagnosed cancer and the second leading cause of cancer death in U.S. women. The studies presented in this …
The mechanical interaction between the cells and their extracellular matrix (ECM) plays a fundamental role in the various biological process such as cancer metastasis, traumatic …
Neuroblastoma accounts for 15% of all pediatric cancer-related deaths, with a 60% survival rate for high-risk patients. MYCN-amplified neuroblastoma tumors in particular progress more quickly …
Leukemic cells evade treatment and host defenses through a multitude of methods that include the impairment of the immune system. Immunotherapeutic protocols have focused on …
This study aimed to evaluate the following (1) Rates and patterns of screening for HCV within a cohort born between1945-65 (“Baby-boomers”) seen at 7 primary …