Characterizing the morphology of the carpometacarpal (CMC) joint and how it changes with osteoarthritis progression is important for understanding the pathoetiology of this multifactorial disease. …
Humans have a unique opposable thumb that maintains a fine balance between mobility and stability to allow motions that span from precision handling to power …
Matrilin-3 (MATN3) is a member of the matrilin family of extracellular matrix (ECM) proteins. It is specifically found in cartilage where it is classically believed …
MicroRNAs (miRNAs) are critical post-transcriptional regulator which silence mRNAs in a precise, highly regulated manner. They are essential for the development and maintainance of skeletal …
MicroRNAs (miRNAs) are conserved post-transcriptional regulators which epigenetically suppress mRNAs in precise, highly regulated yet convoluted manners. MiRNAs are essential for the development and maintenance …
Menisci are essential for long-term knee joint function. Injuries to the menisci are common. Meniscal tears are often treated with arthroscopic partial meniscectomy (PM), a …
Articular cartilage is a smooth, load bearing tissue that lines the ends of bones in articulating joints. Smooth joint motion is facilitated by synovial fluid, …
Articular cartilage is a smooth, load bearing tissue that lines the ends of bones in articulating joints. Smooth joint motion is facilitated by synovial fluid, …
Previous study in our lab demonstrates that SHP2 deletion drives the chondrogenic differentiation of Prrx1+ osteochondroprogenitors both in vitro and in vivo. The goal of …
Background: PTOA and ACL pathologies are tightly associated. Animal models can be utilized to understand the pathology of PTOA and subsequent ACL damage. Hypothesis: We …
Crucial for dictating thumb function is the thumb carpometacarpal (CMC) joint, where the first metacarpal (MC1) meets the trapezium (TPM). CMC osteoarthritis (OA) is prevalent …
This work discusses the unique tribological and anti-inflammatory properties of the glycoprotein lubricin in relation to arthritis. The first aim investigates changes in friction and …
Tribology is the study of friction, wear, and lubrication. For the past several decades, the engineering principles of tribology have been used in attempts to …