Liver transplantation remains the standard of care for liver failure but is constrained by a shortage of organs. Fetal hepatic cell transplantation (HCT) offers a …
There is a high demand for developing a computational platform for global analysis of position- specific sequence variation within HIV-1 subtypes. Undesirable probe designs can …
Antimicrobial resistance poses a global challenge to human health that is only expected to increase without significant treatment innovations. Novel therapeutic strategies are needed for …
Candida albicans is an opportunistic human fungal pathogen that can adapt to fluctuating host environments by both genetic and epigenetic mechanisms. In this study, the …
Abstract of ``Characterization of 2D and 3D Models of Particle-Induced Fibrogenesis'' by Alysha E. Simmons, Ph.D., Brown University, October 2020 Pulmonary fibrosis is a chronic, …
Due to the aggressiveness of TNBC and the relatively large proportion of reproductive-age women this disease afflicts, there is a critical need to develop novel …
Metastatic colorectal cancer (mCRC) has a five-year relative survival rate of 14%. Most patients receive 5-FU (F) and folinic acid (FOL) combined with oxaliplatin (OX), …
The trypanosomatid Trypanosoma brucei and other closely-related parasites cause a broad range human illnesses that affect millions worldwide and lack effective treatment options. A conserved …
The human microbiome contributes to a number of physiological processes, including digestion, neurological development, and proper immune function. Due to its central role in human …
The research presented in this thesis aims to examine the role of varied cadherin expression on transformed cells and how this impacts disease severity and …
Manganese (Mn) is an essential trace metal but is toxic in excess. Mn excess typically manifests as a Parkinson’s-like disorder known as manganism. Therefore, levels …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of motor neurons that affects at least 30,000 people in the United States at any one time …
The pulmonary vascular system facilitates the movement of deoxygenated blood away from the right ventricle of the heart, through the lungs and oxygenated blood from …
Carbon nanomaterials are under development for diverse commercial applications ranging from conductive films to oil dispersants. Either through intended use or accidental release, the potential …
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease involving the uncontrolled scarring of the alveolar epithelium and lethal reduction in ability to breathe. …
Formaldehyde is the most abundant endogenous aldehyde with exogenous exposures being associated with a range of adverse health effects, including neurotoxicity, bone marrow damage and …
Host-microbe interactions heavily influence both fitness and disease. Traditionally, research on host-microbe interactions focused on the concept that microbes only contribute to pathogenesis. However, recent …
Pollution, the release of chemicals into the environment, is the result of current and historic industrial and waste management practices and a range of human …
Objective: There are 240 million cases of malaria each year, making it one of the most endemic diseases in modern history. However, not substantial preventative …