Aberrant endothelial cell (EC) proliferation plays an important role in the vascular remodeling observed in Pulmonary Arterial Hypertension (PAH). Anoctamin-1 (Ano1), a calcium activated chloride …
In the spinal cord dorsal horn, persistent changes in synaptic strength may contribute to nociceptive information processing and to pathological pain states. These changes overlap …
Nicotinic acetylcholine receptors (nAChRs) mediate excitatory neurotransmission at synapses throughout the body in the neuromuscular junction and the central nervous system. The two basic types …
Sigma receptors are a unique pharmacologically defined class of drug-binding proteins comprised of the sigma-1 and sigma-2 subtypes. These subtypes are differentiated by their pharmacological …
We performed a comparative transcriptomic analysis of lightly versus darkly pigmented human epidermal melanocytes (HEMs) using high throughput RNA sequencing (RNA-Seq). We identified 16 genes …
Exposure of human skin to solar ultraviolet radiation (UVR), a powerful carcinogen comprising ~95% UVA wavelengths (320-400 nm) and 5% UVB wavelengths (280-320 nm) at …