Neurodegenerative disease is one of the greatest yet poorest understood medical challenges facing humanity today. A fundamental hurdle that continues to frustrate therapeutic development is …
This combined EEG/pupillometry study examined whether activity within the locus coeruleus-noradrenergic (LC-NA) system can be elicited by infrequent stimuli under both bottom-up (stimulus driven) and …
Background: Microsimulation models (MSMs), belonging to a class of statistical models that perform simulations at the level of individual units, often persons, have been used …
The MuSK-BMP pathway is an important regulator of adult stem cell proliferation, and the immunoglobulin-like 3 domain (Ig3) of the MuSK receptor is required for …
Cellular heterogeneity is inherent in the brain, and resolving differential cell type-specific contributions to overall function is critical for understanding both normal and pathological neurobiology. …
Abstract of Comparative Effectiveness of EFA and MFA for Estimation of Alzheimer’s Disease Cognitive Biomarkers , by Joanna Walsh, Sc.M., Brown University, May 2022. Exploratory …
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that causes progressive memory loss and cognitive decline. AD is associated with neuropathological hallmarks of beta amyloid …
Background: Brain insulin resistance and deficiency are well-recognized abnormalities in Alzheimer’s disease (AD) and likely mediators of impaired energy metabolism. Since apolipoprotein E (APOE) is …
The phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is essential for cell survival, growth, proliferation, and differentiation. It is highly conserved and …
Optical coherence tomography (OCT) is becoming increasingly popular for neuroscientific study, but it remains challenging to objectively quantify tissue and vascular properties from 3D or …
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive impairment in cognitive ability and memory loss. On a pathological and molecular level, AD has …
Alzheimer’s is a debilitating neurodegenerative disease that results in memory loss, difficulty with language and learning, and overall impairments in everyday life. Currently, there is …
Sirtuins are a class of NAD+-dependent deacylases, which regulate diverse functions in mammals, including several related to the aging process. The Drosophila melanogaster ortholog of …
Our aging population is rapidly growing as is the prevalence of neurodegenerative diseases (NDs) like Alzheimer’s Disease. NDs can significantly impair one’s cognitive and motor …
