Problem: Alzheimer’s disease and related dementias (ADRD) affect approximately 10.7% of adults in the United States aged 65 years and older and 48% of nursing …
Plasma p-tau181 is an increasingly established diagnostic marker for Alzheimer’s disease (AD); however, its precise relationship with brain tau pathology and the neural mechanisms underlying …
Neurodegenerative disease is one of the greatest yet poorest understood medical challenges facing humanity today. A fundamental hurdle that continues to frustrate therapeutic development is …
This combined EEG/pupillometry study examined whether activity within the locus coeruleus-noradrenergic (LC-NA) system can be elicited by infrequent stimuli under both bottom-up (stimulus driven) and …
Background: Microsimulation models (MSMs), belonging to a class of statistical models that perform simulations at the level of individual units, often persons, have been used …
The MuSK-BMP pathway is an important regulator of adult stem cell proliferation, and the immunoglobulin-like 3 domain (Ig3) of the MuSK receptor is required for …
Adult Hippocampal Neurogenesis (AHN) is the process through which newborn neurons are born and integrated into brain circuitry. Patients with conditions like Alzheimer’s Disease (AD) …
Cellular heterogeneity is inherent in the brain, and resolving differential cell type-specific contributions to overall function is critical for understanding both normal and pathological neurobiology. …
Abstract of Comparative Effectiveness of EFA and MFA for Estimation of Alzheimer’s Disease Cognitive Biomarkers , by Joanna Walsh, Sc.M., Brown University, May 2022. Exploratory …
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that causes progressive memory loss and cognitive decline. AD is associated with neuropathological hallmarks of beta amyloid …
Background: Brain insulin resistance and deficiency are well-recognized abnormalities in Alzheimer’s disease (AD) and likely mediators of impaired energy metabolism. Since apolipoprotein E (APOE) is …
The blood-brain barrier (BBB) has been recently identified as a key factor involved in the origin and pathological progression of Alzheimer’s disease (AD). The BBB …
My career goal is to advance the process by which we design, evaluate, and refine care management interventions for persons living with dementia. All three …
Alzheimer's Disease (AD) is an irreversible neurodegenerative disorder with a decades long clinically asymptomatic phase which makes the early and accurate detection of the disease …
Alzheimer’s disease (AD) is the most common form of dementia, estimated to affect over 6 million individuals in the United States in 20241,2. Despite its …
The phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is essential for cell survival, growth, proliferation, and differentiation. It is highly conserved and …
Optical coherence tomography (OCT) is becoming increasingly popular for neuroscientific study, but it remains challenging to objectively quantify tissue and vascular properties from 3D or …
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive impairment in cognitive ability and memory loss. On a pathological and molecular level, AD has …
Introduction: This thesis investigated whether inherited risk for Alzheimer's Disease (AD), measured by family history, differentiates sleep architecture and sleep-dependent memory consolidation in young adolescents …
Background: Following the Food and Drug Administration’s (FDA) controversial approval of aducanumab, a monoclonal antibody for the treatment of Alzheimer’s disease, CMS used its National …