Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This modification …
SLC13A5 (mIndy, Hindy) encodes a Na+-coupled citrate transporter expressed on the plasma membrane of liver, testes, and brain tissue. SLC13A5 has been identified as a …
The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA. Here, …
The brain is composed of discrete units called neurons. Neurons communicate with each other and form functional circuits, the fundamental computational units of the nervous …
The bone morphogenetic protein (BMP) signaling pathway is an essential regulator of developmental and cellular processes. Secreted ligands initiate BMP signaling by binding to a …
In male Drosophila, the Dosage Compensation Complex (DCC) is targeted, via a transcription factor (TF), called the Chromatin-linked Adaptor for MSL complex (CLAMP), to the …
Transposable elements (TEs) are parasitic mobile sequences of DNA that proliferate throughout host genomes by replicating and reinserting themselves into new regions of DNA. This …
Effective treatments of alcohol use disorder (AUD) have remained elusive largely because the underlying mechanisms of this devastating disorder are poorly understood. Fruit flies form …
Genetically determined, fixed action pattern behaviors offer a useful model for studying how developmental gene expression programs lay down a neuroanatomical architecture that underlies these …
