BioLuminescent-OptoGenetic molecules for driving and imaging neural activity have a number of advantages in vivo. In this approach, genetically expressed luciferases bind with injected luciferins …
In BioLuminescent driven OptoGenetics (BL-OG) a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. When light emitter …
In BioLuminescent driven OptoGenetics (BL-OG) a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. When light emitter …
The Bioluminescence Hub, a National Science Foundation NeuroNex Technology Hub, is dedicated both to the development of novel bioluminescent and optogenetic tools and to the …
Fluorescence-based optogenetic tools are powerful methods for dissecting cell-type specific circuit dynamics in the nervous system. These tools, however, rely on external, generic modification of …
Interluminescence is a method for selective modulation of synaptic communication between genetically defined partners. Bioluminescent light from a pre-synaptic released luciferase activates a post-synaptic localized …
Using optogenetics, we can manipulate neuronal activity using light. Due to the young age of the animals used in this study, a non-invasive light source …
In BioLuminescent OptoGenetics (BL-OG), the light sensing opsin, such as a channelrhodopsin or a pump, is activated by biological light emitted from a luciferase that …
This recorded interview is the fifth in our Interviews with Experts series and features Peter Hegemann, PhD, Professor and Head of the Department for Biophysics …
This recorded interview is the third in our Interviews with Experts series and features Stefan Herlitze, PhD, Neuroscientist and Faculty of Biology and Biotechnology at …
Using neuroscientists' tools of the trade one can image in independent animals either the brain or the spinal cord. Yet understanding many biological processes such …
Despite ever improving treatment methods, there still is no way to effectively restore function after spinal cord injury. A promising approach is to re-engage spinal …
A non-invasive and highly specific approach to neuronal stimulation is bioluminescent-optogenetics, where genetically expressed light emitting luciferases are tethered to light sensitive channelrhodopsins (luminopsins, LMO); …
The amount and pattern of neuronal activity present during the early developmental period is believed to guide structural and functional properties of neural circuit assembly. …
The amount and pattern of neuronal activity present during the early developmental period is believed to guide structural and functional properties of neural circuit assembly. …
Almost 30 years after identifying the genetic mutation underlying Huntington’s disease (HD), treatments remain limited to managing late-stage symptoms of motoric, psychiatric, and cognitive deficits. …
Bioluminescent molecules for imaging and modifying neural activity are increasingly becoming viable tools for in vivo use and have the potential to overcome many of …
As an alternative to fluorescent imaging, we are developing calcium-dependent, genetically-encoded molecules using bioluminescent probes. Bioluminescence is chemically generated light that occurs when a photon-containing …
Biological light activation of optogenetic sensors across synaptic partners offers the potential to optogenetically dissect synaptic communication non-invasively. The genetically encoded light source, a luciferase, …