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Examining behavioral differences in alcohol preferring and non-preferring Drosophila

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Overview

Year:
2020
Contributor:
Glenn, Eve (creator)
Hernandez, John (creator)
Kaun, Karla (creator)
Karla Kaun (advisor)
Brown University. Karen T. Romer Undergraduate Teaching and Research Awards (research program)
Genre:
posters
Subject:
Alcohol
Drosophila
Memory
Extent:
1 poster

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Description

Abstract:
Understanding individuals’ choice to self-administer drugs of abuse is an ongoing endeavor. Drosophila is an excellent model to investigate this due to the impressive temporal and spatial resolution for manipulating neurons within a memory circuit. We have developed a 3-day Open Bar assay that allows flies to self-administer rewards by entering a Region of Self-Administration (ROSA), which triggers the flow of volatilized 50% ethanol into the chamber. We hypothesized that flies that increase ethanol self-administration across three days will differ in subtle behaviors during ethanol self-administration compared to flies that decrease ethanol self-administration. We found that wild-type increase (escalators), do not change (stable), or decrease (de-escalators) their time in the ROSA within the first and third day of administration. We found a significant correlation between velocity and time spent in the ROSA. We conclude subtle behavioral measurements like velocity are indicators of self-administration patterns.

Content

Citation

Glenn, Eve, Hernandez, John, and Kaun, Karla, "Examining behavioral differences in alcohol preferring and non-preferring Drosophila" (2020). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://repository.library.brown.edu/studio/item/bdr:1138475/

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    Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
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