Description
- Abstract:
- Importance: Traumatic brain injury (TBI) has been repeatedly shown to be a risk factor for several neurodegenerative diseases. However, no studies have yet examined TBI as a risk factor for corticobasal degeneration (CBD) or corticobasal syndrome (CBS), and few have examined progressive supranuclear palsy (PSP) in relation to TBI. Objective: Determine TBI’s relation to the age at onset (AAO) of cognitive decline in PSP, CBS, and CBD and to the prevalence of PSP and CBD neuropathology. Design: This is a retrospective observational study using the National Alzheimer’s Coordinating Centers (NACC) database. The most recent assessment of participants was used as of June 2018, including participant visits which occurred between 2005 and 2018. Setting: NACC is a multicenter dataset with standardized data collection procedures. Participants: The NACC dataset includes a total of 38,249 participants. 101 (14 TBI+) participants were included with clinical (antemortem) diagnoses of PSP and 137 (16 TBI+) with CBS. It also includes 2,743 autopsy samples, including 120 (14 TBI+), 58 (7 TBI+), and 11 (1 TBI+) with neuropathological (autopsy) diagnoses of PSP, CBD, or both, respectively. 181 (21 TBI+) of the participants with autopsy diagnosed PSP or CBD had antemortem cognitive decline. Exposure: Self-reported history of TBI. Main Outcomes: Clinician estimated AAO of cognitive decline and prevalence of neuropathological diagnosis of CBD and PSP. Results: TBI is associated with a significant 4-year earlier AAO of cognitive decline among participants with an antemortem diagnosis of CBS and a 6-year earlier AAO in participants with autopsy diagnosed PSP. Additionally, TBI among participants with autopsy diagnosed CBD without concomitant Alzheimer’s disease (AD) neuropathology was associated with a 7-year earlier AAO of cognitive decline (p=.066). History of TBI was not significantly associated with the prevalence of PSP and/or CBD pathology postmortem. Conclusions and Relevance: This is the first report linking TBI with an earlier onset of cognitive decline in CBS and in neuropathologically defined PSP.
- Notes:
- Scholarly concentration: Non-Scholarly Concentrator
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Citation
Spiegel, Jonathan, Sone, Je Yeong, Butler, Tracy, et al.,
"Traumatic Brain Injury and Age at Onset of Cognitive Decline in Corticobasal Degeneration, Corticobasal Syndrome, and Progressive Supranuclear Palsy"
(2020).
Warren Alpert Medical School Academic Symposium.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/t9md-x744
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Warren Alpert Medical School Academic Symposium
The Warren Alpert Medical School Academic Symposium is an annual event at Warren Alpert Medical School of Brown University that provides Year II medical students a venue to present their summer research in a poster format. Participation in the Symposium …...