Epigenetics, Neurobehavior, and Toxic Stress in Children with Prenatal Methamphetamine Exposure

Oni-Orisan, Oluwadamilola

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Year:: 2017
Contributor:: Oni-Orisan, Oluwadamilola (creator); Lester, Barry (Advisor); Pearlman, Deborah (Reader); Brown University. School of Public Health (sponsor)
Genre:: theses
Subject:: epigenetics
Extent:: v, 47 p.
DOI: https://doi.org/10.7301/Z08S4NCS

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Abstract:: Objective: To assess the association between prenatal methamphetamine exposure (PME) and methylation of the gene 11-Beta hydroxysteroid dehydrogenase type 2 (11B-HSD2) Methods: The Infant Development, Environment, and Lifestyle Study (IDEAL), a prospective, longitudinal study of PME and child outcomes enrolled postpartum mother-infant dyads in California, Hawaii, Iowa, and Oklahoma. Prenatal exposure was defined by maternal self-report and/or meconium toxicology screening. Exposed and comparison groups were matched on race, birth weight, health insurance, and education in the original study. In this study at ages 10-11 years, 100 dyads from California and Hawaii were assessed for drug exposure and methylation of the gene 11B-HSD2. Hierarchical linear models were used to determine the association between PME and methylation of 11B-HSD2 with adjustment for early childhood adversity and cortisone level. Results: Methamphetamine (MA) exposure and early childhood adversity were statistically significant predictors of methylation of 11B-HSD2 at the CpG2 site. Conclusion: This is the first evidence of MA exposure as a stressor on child neurobehavior, which confirms the third pathophysiology of MA, and the first report of the epigenetic stress model in the context of MA use.
Notes:: Thesis (M. P. H.)--Brown University, 2017

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Rights: In Copyright
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Citation

Oni-Orisan, Oluwadamilola, "Epigenetics, Neurobehavior, and Toxic Stress in Children with Prenatal Methamphetamine Exposure" (2017). Public Health Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.7301/Z08S4NCS

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Public Health Theses and Dissertations

Theses and Dissertations for the Public Health department.
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