Microelectrode arrays are used to record neural signals in patients and can be used to restore or replace lost function to these patients. A major problem with these devices is that the body recognizes the arrays as a foreign body. The body’s inflammatory response hinders the device’s ability to record action potentials and thus reduces the long-term effectiveness of microelectrode arrays. In order to study this inflammatory response, we are using in-vitro models that closely mimic in-vivo environments. To properly study the best way to mitigate the body’s inflammatory response we hope to record from electrodes chronically and see how different treatments affect the electrode’s ability to acquire a signal. This project focuses on developing a system that can record from electrodes and transmit that data to a remote server. This system would enable researchers to access recordings from electrodes implanted microtissues at all times which would allow them to see how the signal changes over time and which treatments are most effective at preventing the degradation of signal.
Syrop, Sarah Louise,
"System for Chronic In-Vitro Neural Cell Culture Recordings and Data Transmission"
(2018).
Biomedical Engineering Theses and Dissertations.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/rv1h-tt11
