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Mathematical model of neocortex predicts that dendritic calcium spikes are visible in human EEG signals

Description

Abstract:
Computational modeling is a powerful tool for studying how the activity of cells in a neural network is read out into human electroencephalography (EEG) signals. Suzuki and Larkum (2017) found that calcium spikes in the dendrites of layer 5 neocortical pyramidal neurons (PN) are visible in recordings on the cortical surface of rats. We used our lab’s model of neocortex to investigate and expand on this claim in relationship to human EEG. After adapting the model PNs to have more realistic electrophysiological properties, we found calcium spikes are indeed visible in the EEG. Furthermore, calcium spikes are visible in the absence of somatic spiking, and the polarity of the corresponding EEG indicates the direction of calcium flow in the dendrite.

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This work is licensed under a All rights reserved license

Citation

Pugliese, Sarah, and Jones, Stephanie, "Mathematical model of neocortex predicts that dendritic calcium spikes are visible in human EEG signals" (2019). Summer Research Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/gp2h-m470

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  • Summer Research Symposium

    Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
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