The All of Us Research Program is dedicated to collecting electronic health records, surveys, and biosamples data representing the diversity of the US population, with particular focus on recruiting participants from groups typically underrepresented in biomedical research. It is important to understand how data from the program has been used in order to use the database most effectively in the future. A literature review was conducted to understand what populations have been studied using the All of Us Researcher Workbench, what methodologies have been used, and what gaps may exist to inform future studies. The review identified 106 articles in PubMed published between 2021 and 2023, which analyzed All of Us data. These studies covered a wide range of topics, including dermatological conditions, stroke, glaucoma, and other conditions. Certain studies also focused on particular sociodemographic groups such as Black and Hispanic patients or disparities between groups, while others sought to identify comorbidities for particular conditions. The literature review revealed that despite the increasing prevalence of pediatric anxiety and depression, the All of Us Research Program has not yet been used to characterize this population. Studies have shown that racial and gender minorities may be at increased risk for these mental health disorders. Therefore, data from All of Us could help with better understanding which groups are most at risk for developing anxiety or depression and what comorbidities may be associated with these conditions. As part of a preliminary study, demographics and comorbidities for pediatric anxiety and depression are being analyzed using the All of Us Researcher Workbench. The prevalence of anxiety and depression in the pediatric population will be calculated and odds ratios will be used to assess relative risk by gender and race. All of Us data will also be used to identify comorbidities. Overall, the findings from this study have the potential to advance our understanding of pediatric anxiety and depression within underrepresented populations, providing insight to inform targeted interventions and improve healthcare outcomes.
Srinivasan, Anusha,
"Characterizing Pediatric Anxiety and Depression in the All of Us Researcher Workbench"
(2023).
Summer Research Symposium.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/6emy-2a51
Each year, Brown University showcases the research of its undergraduates at the Summer Research Symposium. More than half of the student-researchers are UTRA recipients, while others receive funding from a variety of Brown-administered and national programs and fellowships and go …
