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Items (201-209) out of 209 results

Translational control and active transport of Vg1 mRNA in Xenopus laevis oocytes

Description:
mRNA localization is a powerful post-transcriptional mechanism of gene expression that allows for protein expression in distinct cellular locations. This process is exploited in a …
Year:
2013
Contributor:
Pratt, Catherine A (creator)
Mowry, Kimberly (Director)
Dahlberg, Albert (Reader)
Laney, Jeffrey (Reader)
Reenan, Robert (Reader)
Vasudevan, Shobha (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
mRNA localization
translational repression
Vg1
miRNA
Argonaute
Xenopus laevis
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Transposable Element Activation in Somatic Tissues Impacts Drosophila Physiology and Lifespan

Description:
Transposable elements (TEs) are parasitic mobile sequences of DNA that make up large percentages of their host genomes. Because of their ability to move about …
Year:
2017
Contributor:
Jones, Brian C (creator)
Helfand, Stephen (Advisor)
Reenan, Robert (Reader)
Larschan, Erica (Reader)
Neretti, Nicola (Reader)
Dubnau, Joshua (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Molecular biology
Metabolism
Lipids--Metabolism
Drosophila melanogaster
Transposons
Small interfering RNA
Non-coding RNA
Adipose tissues
fat body
RNA interference
RNAi
Piwi genes
piwi
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Ubiquitin-Dependent Proteolysis of the Yeast Mating-Type Regulator Matalpha1

Description:
Cell type in budding yeast is controlled by the master regulatory transcription factors encoded at the mating-type (MAT) locus Mat?1, Mat?2, and Mata1. In homothallic …
Year:
2009
Contributor:
Nixon, Christina Erin (creator)
Laney, Jeffrey (director)
Landy, Arthur (reader)
Mowry, Kimberly (reader)
Freiman, Richard (reader)
Johnson, Erica (reader)
Brown University. Division of Biology and Medicine. Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
MATalpha1
ubiquitin-proteasome system
protein degradation
mating-type switching
SUMO
Slx5
Slx8
Ufd4
Ubc13
Ubc4
Ubc5
Yeast
Proteolysis
Language:
English
Collection:
Biology and Medicine
Theses and Dissertations
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Use of Inducible, Selectable and Stable Fluorescent Protein-Tagged 5-HT2 Receptors in Elucidating JC Polyomavirus Cellular Entry and Trafficking

Description:
JC Polyomavirus (JCPyV) is a human pathogen which in immunocompromised individuals causes progressive multifocal leukoencephalopathy (PML), a fatal central nervous system disease. All three variants …
Year:
2019
Contributor:
Atkinson, Abigail (creator)
Atwood, Walter (thesis advisor)
Assetta, Benedetta (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Polyomavirus infections
Serotonin--Receptors
Molecular biology
Genetic vectors
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Using positional frequency distribution to identify functional splicing elements and predict pre-mRNA processing defects in human genes

Description:
We present an intuitive strategy for predicting the effect of sequence variation on splicing. In contrast to transcriptional elements, splicing elements appear to be strongly …
Year:
2012
Contributor:
Lim, Kian Huat (creator)
Fairbrother, William (Director)
Freiman, Richard (Reader)
Brodsky, Alexander (Reader)
Zervas, Mark (Reader)
Aalberts, Daniel (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
alternational splicing
genetic diseases
pre-mRNA splicing
Computational biology
Bioinformatics
Genetic disorders
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Using X-ray crystallography to determine the effect of the antibiotic streptomycin on bacterial protein translation

Description:
My goal was to understand the role of streptomycin, an antibiotic from the aminoglycoside class and the original treatment for tuberculosis, in inhibiting bacterial protein …
Year:
2017
Contributor:
Rangwala, Aziz M. (author)
Jogl, Gerwald (advisor)
Brown University (sponsor)
Genre:
theses
Subject:
Drug Resistance, Microbial
Crystallography
Ribosomes
Streptomycin
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Chemistry
Theses and Dissertations
Full Record

Viral and Host-Cell Factors Critical for JC Virus Infection

Description:
JC virus (JCV) is the causative agent of Progressive Multifocal Leukoencephalopathy, a fatal demyelinating disease of the central nervous system (CNS). This disease is caused …
Year:
2009
Contributor:
Gasparovic, Megan L. (creator)
Atwood, Walter (director)
Serio, Tricia (reader)
Freiman, Richard (reader)
Salomon, Arthur (reader)
DiMaio, Daniel (reader)
Brown University. Division of Biology and Medicine. Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
JC virus
JCV
PML
ND10
minor proteins
virus trafficking
Language:
English
Collection:
Biology and Medicine
Theses and Dissertations
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Visualization of Microbial Communities Using Fluorescence In Situ Hybridization and Spectral Imaging Technology

Description:
Fluorescence in situ hybridization (FISH) is a molecular labeling technique that can be used to visualize and taxonomically identify microbial cells. In this study, spectral …
Year:
2013
Contributor:
Hasegawa, Yuko (creator)
Sogin, Mitchell (Director)
Borisy, Gary (Director)
Gerbi, Susan (Reader)
Rand, David (Reader)
Brodsky, Alexander (Reader)
Huber, Julie (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Fluorescence In Situ Hybridization
Gut Microbes
Microbial Spatial Patterns
Fluorescence in situ hybridization
Spectral imaging
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

β1-Integrin Signaling Underlies the Phenotypic Changes of the Bladder in a Novel Mouse Model of Acute Urinary Retention: An in vivo Application of Mechanobiology

Description:
Acute urinary retention (AUR), or the sudden inability to empty the bladder completely, can result in permanent impairment of bladder smooth muscle (BSM), also known …
Year:
2021
Contributor:
Chan, Daniel (creator)
Tapinos, Nikos (thesis advisor)
Yu, Weiqun (thesis advisor)
Kroetz, Deanna (thesis advisor)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Integrins
Molecular biology
Bladder
Urology--Research
Mechanoreceptors
Animal models in research
Cellular signal transduction
Muscle contraction--Regulation
Urinary incontinence
Urinary organs
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Items (201-209) out of 209 results