BACKGROUND: Substance use disorder (SUD), characterized by the compulsive use of alcohol and other drugs despite harmful consequences, is a widespread and growing public health …
Background: Alcohol elevates sympathetic nervous system (SNS) activity, which should result in an overall increased heart rate (HR) during sleep. We propose to examine HR …
Neural circuits give direct insight into cognition, behavior, and various disease states. A circuit’s connectivity largely determines its role, highlighting the importance of circuit mapping. …
An important goal in neuroscience is to understand how experience affects the selection, execution and maintenance of different action plans, and how this is reflected …
Sequence processing is a cognitive function underlying many daily tasks, for example, following the steps to make a cup of coffee. Adequate sleep is critical …
Temperature is a fundamental property that affects all biologic systems, including the brain. The high temperatures of fever states can trigger febrile seizures in children, …
This work presents several experiments designed to explore the use of spatial memory by echolocating big brown bats (Eptesicus fuscus) through observable flight behavior, specifically …
Over the last few decades, scientists have begun to fully recognize the importance of astroglia in synaptic formation and function. The perisynaptic glial processes are …
The exquisite morphology of neurons requires responses to stimuli in a spatially regulated manner. One means to achieve spatially-restricted control is through local translation, where …
Abstract of “Functional and Anatomical Pathways Supporting the Cognitive Control of Memory Retrieval” by Jennifer Barredo, Brown University, May 2014. Functions of the left ventrolateral …
In recent years, attempts at mapping neuronal circuitry have become more effective with the advent of new technologies that can label precise synapses and provide …
The primary objective of this thesis is to investigate the consequences of TSC1 gene deletion in a subcortical brain structure, the thalamus, during embryonic development. …
Many monoaminergic antidepressants increase the birth of new neurons in the adult hippocampus, supporting a neurogenic hypothesis of depression. Current antidepressant treatment is characterized by …
The ability to learn task structure and perform well according to task rules and organization declines across healthy aging in humans, especially in cognitive tasks …
The blood-brain barrier (BBB) has been recently identified as a key factor involved in the origin and pathological progression of Alzheimer’s disease (AD). The BBB …
Work in the last ten years has demonstrated the existence of a third class of light-sensing neurons in the mammalian retina, intrinsically-photosensitive retinal ganglion cells …
When groups of neurons are synchronously and rhythmically active, they give rise to electrical oscillations that can be seen in the surrounding extracellular local field …
Precise computation of sensory and contextual information in the mammalian neocortex and hippocampus relies on reciprocally connected networks of excitatory glutamatergic principal cells and inhibitory …