JC polyomavirus (JCPyV) is a small non-enveloped virus that establishes lifelong, persistent infections in the majority of the adult population. Immune-competent patients are generally asymptomatic, …
The primary objective of this thesis is to spatially and temporally dissect the role of WNT1 in cerebellum (Cb) development. During embryogenesis, the Cb is …
Human exposure to mixtures of environmental chemicals occurs daily, leading to challenges regarding risk assessment due to limited information on these interactions. This dissertation developed …
Trinucleotide repeats (TNRs) occur throughout the genome and their expansion can affect varied cellular processes such as gene expression, mRNA processing, and protein folding. TNR …
Genetically determined, fixed action pattern behaviors offer a useful model for studying how developmental gene expression programs lay down a neuroanatomical architecture that underlies these …
Diabetes mellitus results from gradual decline in pancreatic beta cell mass and function. Cell-based therapies in diabetes research are mainly focused on using stem cells …
Triple negative breast cancer (TNBC) is a heterogenous form of breast cancer known for its poor prognoses and lack of reliable treatment options due to …
We present an intuitive strategy for predicting the effect of sequence variation on splicing. In contrast to transcriptional elements, splicing elements appear to be strongly …
