Brown University

Search Results

Active filters

CollectionMolecular Biology, Cell Biology, and Biochemistry Cancel selected facet

Refine your results

Items

Items (41-60) out of 209 results

Development of a novel imaging system for automated high-throughput drug screening in zebrafish

Description:
Worldwide, 253 million people are afflicted with visual impairment. The development of novel therapies for the prevention and treatment of visual disorders is necessary 1. …
Year:
2019
Contributor:
Baek, Peter (creator)
Créton, Robbert (thesis advisor)
Hoffman-Kim, Diane (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Vision
Zebra danio
High throughput screening (Drug development)
Drugs
Fishes--Larvae
Imaging systems
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Development, Disease, and Regeneration: Using Zebrafish to Model Neurological Perturbations

Description:
As medical technologies advance, effective vertebrate models of human disease are vital to determine safety and efficacy of treatments. My research has further developed zebrafish …
Year:
2018
Contributor:
Thorn, Robert Joseph (creator)
Hart, Anne (Reader)
Wessel, Gary (Reader)
Creton, Robbert (Advisor)
Mowry, Kimberly (Reader)
DeLong, Alison (Reader)
Aluru, Neel (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Zebrafish
Brain Development
Brain--Diseases
Zebrafish Behavior
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Differential Gene Expression in the Fungus Fly, Sciara coprophila: The Quest for Stable Reference Genes

Description:
Strict regulatory mechanisms ensure that the cell’s genome is perfectly duplicated. In eukaryotic cells, origins of replication fire once and only once per cell cycle. …
Year:
2017
Contributor:
Lee, Audrey (creator)
Gerbi, Susan (Advisor)
Wharton, Kristi (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Sex determination, Genetic
DNA amplification
Gene expression
Sciara
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Differential regulation of gene expression in D. melanogaster is mediated by context-specific functions of the essential CLAMP transcription factor

Description:
Defining diverse roles of a single transcription factor on the cellular level is key to understanding its role in the context of an organism. However, …
Year:
2017
Contributor:
Urban, Jennifer Anne (creator)
Larschan, Erica (Advisor)
Wharton, Kristi (Reader)
Kaun, Karla (Reader)
Neretti, Nicola (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Drosophila melanogaster--Genetics
Genomics
Transcription factors
Chromatin
Sex determination, Genetic
dosage compensation
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Discovery and Examination of New Genes Affecting Transposable Element Regulation in Drosophila melanogaster

Description:
Transposable elements (TEs) are genetic elements that can move around the genome, causing mutations and genomic instability. These "jumping" genes are ubiquitous in the genomes …
Year:
2019
Contributor:
Kim, Dowon (creator)
Helfand, Stephen (thesis advisor)
Taylor, Jackson (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Aging
Transposons
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Dissecting the role of dosage compensation in brain development in Drosophila melanogaster

Description:
Regulation of gene expression is an essential process in all cell types, from stem cells to neurons. A key aspect of gene expression that remains …
Year:
2016
Contributor:
Xu, Lucy (author)
Larschan, Erica (advisor)
Kaun, Karla (reader)
Genre:
theses
Subject:
Epigenetics
Gene expression
Brain development
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Diverse subtypes of fast-spiking inhibitory neurons in neocortex

Description:
Inhibitory interneurons are essential for normal cortical function. They prevent seizures, regulate temporal and spatial coding, and generate oscillations and synchrony in pyramidal cells. The …
Year:
2015
Contributor:
Sugden, Arthur U (creator)
Connors, Barry (Director)
Cruikshank, Scott (Director)
Barnea, Gilad (Reader)
Berson, David (Reader)
Jaworski, Alexander (Reader)
Harwell, Corey (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
inhibitory
gamma
parvalbumin
fast-spiking
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Diversification of Protein Phosphatase 2A Regulatory Subunits in Plants: Functional and Phylogenetic Analysis

Description:
Protein Phosphatase 2A (PP2A) is heterotrimeric enzyme that regulates key signaling pathways in eukaryotes by dephosphorylating target proteins. PP2A enzymes are composed of a structural …
Year:
2017
Contributor:
Booker, Matthew A (creator)
DeLong, Alison (Advisor)
Johnson, Mark (Reader)
Hart, Anne (Reader)
Welch, David Mark (Reader)
Shiu, Shin-Han (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
ethylene
Protein Phosphatase 2A
gene expansion
ACS6
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Diversification of the SUVH6 Clade of Histone 3 Lysine 9 Methyltransferases in Flowering Plants

Description:
Transposons are parasitic DNA sequences that pose threats to genome stability across a range of eukaryotes. To defend against transposition into essential genes and destabilizing …
Year:
2020
Contributor:
Kotak, Jenna Elizabeth (creator)
Gehring, Mary (Reader)
Bender, Judith (Advisor)
Freiman, Richard (Reader)
Larschan, Erica (Reader)
Johnson, Mark (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Chromatin
Transposons
DNA--Methylation
Evolution (Biology)
Plant molecular genetics
Histone Modifications
Transciptional Regulation
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

DNA Damage in the Aged Subventricular Zone: Methods for Immunofluorescence

Description:
Senescent cells have many harmful effects to the tissue they surround by creating an inflammatory environment and increase DNA damage by inducing retrotransposable elements. With …
Year:
2019
Contributor:
Cespedes Zablah, Andrea (creator)
Kreiling, Jill (thesis advisor)
Miller, Kenneth (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Aging
Neural stem cells
DNA damage
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Drosophila dosage compensation as a model for combinatorial transcriptional regulation

Description:
Biological systems must regulate complex gene transcriptional programs to mediate phenotypic response to diverse stimuli. Control of gene expression requires specific DNA sequence patterns called …
Year:
2019
Contributor:
Jordan, III, William Thomas (creator)
Larschan, Erica (Advisor)
Bender, Judith (Reader)
DeLong, Alison (Reader)
Neretti, Nicola (Reader)
Adelman, Karen (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Molecular biology
Drosophila melanogaster--Genetics
Genomics
dosage compensation
Drosophila melanogaster
Computational biology
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Dynamic expression of TAF4b regulates early mouse oocyte differentiation

Description:
Assisted reproductive therapy and fertility preservation techniques such as freezing eggs are increasingly used to improve or safeguard human reproduction worldwide, yet what factors govern …
Year:
2021
Contributor:
Gura, Megan Ann (creator)
Webb, Ashley (Reader)
Johnson, Mark (Reader)
Larschan, Erica (Reader)
Clark, Amander (Reader)
Freiman, Richard (Advisor)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
RNA sequencing
Gene expression
RNA transcription
oocyte
TAF4b
Turner's syndrome
primary ovarian insufficiency
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Early-Life Antibiotics Modify Risk for Obesity in a Genotype-Dependent Manner by Reshaping the Gut Microbiome

Description:
Early antibiotic exposure is known to disrupt gut microbiome development, yet whether such disruption modifies obesity risk in genetically susceptible individuals, and its possible microbial …
Year:
2026
Contributor:
Curtis-Joseph, Noelle (creator)
Belenky, Peter (Advisor)
Tatar, Marc (Reader)
Ayala, Alfred (Reader)
Beura, Lalit (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Diabetes
Antibiotics
gut microbiome
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Ecdysone-Regulated DNA Amplification in Sciara coprophila

Description:
Abstract of ‘Ecdysone-Regulated DNA Amplification in Sciara coprophila’, by Léo Kadota, Sc.M., Brown University, May 2017. The eukaryotic genome contains thousands of origins (ORIs) of …
Year:
2017
Contributor:
Kadota, Léo (creator)
Gerbi, Susan (Advisor)
Helfand, Stephen (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
DNA replication
sciara coprophila
DNA amplification
DNA puffs
Sciara
Ecdysone
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

EFFECTS OF CHRONIC ETHANOL CONSUMPTION ON SPLENIC DENDRITIC CELL FUNCTIONS

Description:
About 7.1% of Americans older than 18 have been reported to abuse alcohol. Chronic alcoholics are more susceptible to infections. In this regard, higher incidences …
Year:
2011
Contributor:
Eken, Ahmet (creator)
Wands, Jack (Director)
Atwood, Walter (Reader)
Brossay, Laurent (Reader)
Nillni, Eduardo (Reader)
Mandrekar, Pranoti (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Antigen Presentation
Antigen Processing
Ethanol
Alcohol
Dendritic cells
Alcoholic liver diseases
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Elucidating the role of nucleotide-binding oligomerization domain-like receptor X1 in the pathogenesis of pulmonary fibrosis

Description:
This project sought to evaluate the role of a pattern recognition receptor (PRR) called nucleotide-binding oligomerization domain-like receptor protein X1 (NLRX1). It is the only …
Year:
2016
Contributor:
Blum, Alexander J. (author)
Lee, Chang-Min (advisor)
Zhou, Yang (reader)
Genre:
theses
Subject:
Pulmonary fibrosis
NLRX1
Cell culture
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Elucidation of the Molecular Components of the Lck Protein Interaction Network Regulated by PLCɣ1 and PLCɣ2 in Human T Cells

Description:
In the adaptive immune system, T cells play an important role in killing infected cells and recruiting other cells as part of the immune response. …
Year:
2020
Contributor:
Tran, Melanie D. (creator)
Salomon, Arthur (thesis advisor)
Jogl, Gerwald (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
T cells
T cells--Receptors
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Epigenetic regulation of aging by two chromatin-modifying proteins in Drosophila melanogaster

Description:
Retrotransposable element (RTE) mobilization due to heterochromatin loss is among the molecular mechanisms associated with deleterious phenotypes that accompany biological aging. Here, we describe novel …
Year:
2022
Contributor:
Mizerak, Evan (creator)
Helfand, Stephen (thesis advisor)
Taylor, Jackson (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Drosophila melanogaster
Genetics
Aging
Transposons
Heterochromatin
Chromatin
Gene silencing
RNA-seq
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Epigenetic Regulation of Cellular Senescence by WNT-MYC-Polycomb Signaling

Description:
Polycomb Group (PcG) epigenetic regulators are important but not well-understood components of cellular senescence. EZH2, a PcG histone H3 lysine-27 methyltransferase, is repressed in senescent …
Year:
2016
Contributor:
Ito, Takahiro (creator)
Sedivy, John (Director)
Helfand, Stephen (Reader)
Chen, Qian (Reader)
Fairbrother, William (Reader)
Shi, Yang (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Aging
Cellular Senescence
Epigenetics
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Epigenomic and Transcriptional Changes in Cellular Senescence and Aging

Description:
Cellular senescence and aging are associated with extensive chromatin and transcriptional changes. We examined cell-free DNA (cfDNA) in individuals of different age groups to elucidate …
Year:
2019
Contributor:
Teo, Yee Voan (creator)
Neretti, Nicola (Advisor)
Fairbrother, William (Reader)
Webb, Ashley (Reader)
Helfand, Stephen (Reader)
Baur, Joseph (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Genomics
Aging
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Items (41-60) out of 209 results